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- W575255364 abstract "In this Thesis, consisting of five original publications (Publ. I–V) and a summary, the feasibility of the combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) for the study of cortical reactivity and connectivity has been explored in humans. To stimulate the cerebral cortex through electromagnetic induction, a coil of wire was placed above the person’s head and short, intensive current pulses were driven through the coil. Different sites within the sensorimotor and prefrontal cortices were stimulated with various pulse intensities while measuring changes in electric potential with 60 electrodes on the scalp. In some of the experiments, the coil was navigated over the desired cortical area based on individual magnetic resonance images of the head. The reactivity of the stimulated cortical sites was evaluated based on the EEG. A theoretical model for the intensity dependence of the brain response was proposed. The intraand interhemispheric connectivities of the stimulated areas were assessed using minimum-norm current-density estimates (MNE) derived from the EEG. The spatial accuracy of the MNE was assessed by applying it to the estimation of relatively well-known cortical current distributions, i.e., those elicited by electrical stimulation of the median and ulnar nerves. In addition, simulated potential fields of current dipoles were used to address the effect of measurement noise and source depth on the MNE localization accuracy. This Thesis shows that the combination of TMS and high-resolution EEG allows the study of interhemispheric connections with high spatiotemporal specificity and enables the assessment of cortical reactivity, also within non-motor cortical areas, with excellent sensitivity. The localization accuracy of the MNE is shown to be comparable with that of equivalent dipole fitting, and, thus, sufficient for tracing the spread of TMS-evoked activity." @default.
- W575255364 created "2016-06-24" @default.
- W575255364 creator A5069010139 @default.
- W575255364 date "2004-11-01" @default.
- W575255364 modified "2023-09-27" @default.
- W575255364 title "Electroencephalographic responses to transcranial magnetic stimulation" @default.
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