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- W57532323 abstract "Complement is an important effector system of host defense. It consists of more than 35 proteins, which in their native state either circulate as serum-soluble components of the blood or are associated with cellular membranes. Expression of biological activity requires the activation of the system, which results in the production of protein fragments and protein-protein complexes that interact with specific cellular receptors or directly with the lipid bilayer of cell membranes to mediate acute inflammatory reactions, clearance of foreign molecules and cells, killing of susceptible cells, regulation of adaptive immune responses, and other activities (1). These combined effects are necessary for the elimination of pathogenic microorganisms as well as the efficient production of specific antibodies by B cells. However, complement-mediated acute inflammation can also lead to tissue damage under certain conditions such as when an infectious agent cannot be eliminated or when complement activation is initiated by physical injury such as ischemia, burn, or crush injury or by autoimmune reactions (2). In such cases arises the need for effective pharmacological control of the complement activation process and/or its products." @default.
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- W57532323 date "2000-01-01" @default.
- W57532323 modified "2023-09-23" @default.
- W57532323 title "Inhibition of Complement Serine Proteases as a Therapeutic Strategy" @default.
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- W57532323 doi "https://doi.org/10.1007/978-1-59259-017-9_3" @default.
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