Matches in SemOpenAlex for { <https://semopenalex.org/work/W57572793> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W57572793 abstract "In the frame of a large scale gene trap (GT) mutation screening focused on identification of novel genes involved in CNS development and function, a mouse GT line was characterized showing postnatal reporter gene expression in cerebellar Purkinje cells (PC), hippocampus, cortex and retinal ganglionic and inner nuclear layers. Mice homozygous for the Gene Trap mutation were phenotypically indistinguishable from wild type littermates until approximately 1.5 month of age, when intention tremor followed by gait ataxia started to appear. In later stages (around 3 months) episodes of spontaneous epileptic seizures were observed.Histologically, the GT mutant mice suffered from progressive degeneration of Purkinje cells and deep cerebellar nuclei. Innervation of Purkinje cells by climbing fibers was established in the mutant mice but they retracted following degeneration of Purkinje cells. In retina size reduction was detected in ganglion cell layer and inner nuclear layer. The size of the outer plexiform layer that contains dendrites of bipolar cells was also significantly reduced. No degeneration was found in hippocampus.The GT vector insertion was found to occur inside a RBCC/TRIM RING finger domain containing gene trim2 a binding partner of myosin V. Myosin V is, as a motor molecule, responsible for transport of smooth endoplasmic reticulum into the dendritic spines of Purkinje cells. Besides it interacts with neurofilament light subunit (NF-L) and regulates neurofilament density in axons. Since no phenotype was detected in dendrites of Purkinje cells of trim2 mutant mice but Purkinje cell axonal swellings were discovered in already one month old mutants (even before degeneration of Purkinje cells was detected) both in cerebellar white matter and in granule cell layer, we suggest that axonal defect could be the cause of cerebellar phenotype of trim2 mutant mice." @default.
- W57572793 created "2016-06-24" @default.
- W57572793 creator A5028178133 @default.
- W57572793 date "2003-11-25" @default.
- W57572793 modified "2023-09-23" @default.
- W57572793 title "Trim2 mutant mice as a model for cerebellar ataxia" @default.
- W57572793 hasPublicationYear "2003" @default.
- W57572793 type Work @default.
- W57572793 sameAs 57572793 @default.
- W57572793 citedByCount "0" @default.
- W57572793 crossrefType "dissertation" @default.
- W57572793 hasAuthorship W57572793A5028178133 @default.
- W57572793 hasConcept C104317684 @default.
- W57572793 hasConcept C143065580 @default.
- W57572793 hasConcept C153911025 @default.
- W57572793 hasConcept C157207234 @default.
- W57572793 hasConcept C169760540 @default.
- W57572793 hasConcept C203014093 @default.
- W57572793 hasConcept C204232928 @default.
- W57572793 hasConcept C2775845787 @default.
- W57572793 hasConcept C2778472085 @default.
- W57572793 hasConcept C2779652256 @default.
- W57572793 hasConcept C2780148635 @default.
- W57572793 hasConcept C2780393176 @default.
- W57572793 hasConcept C2780680797 @default.
- W57572793 hasConcept C2780906641 @default.
- W57572793 hasConcept C2992333117 @default.
- W57572793 hasConcept C54355233 @default.
- W57572793 hasConcept C86803240 @default.
- W57572793 hasConcept C95444343 @default.
- W57572793 hasConceptScore W57572793C104317684 @default.
- W57572793 hasConceptScore W57572793C143065580 @default.
- W57572793 hasConceptScore W57572793C153911025 @default.
- W57572793 hasConceptScore W57572793C157207234 @default.
- W57572793 hasConceptScore W57572793C169760540 @default.
- W57572793 hasConceptScore W57572793C203014093 @default.
- W57572793 hasConceptScore W57572793C204232928 @default.
- W57572793 hasConceptScore W57572793C2775845787 @default.
- W57572793 hasConceptScore W57572793C2778472085 @default.
- W57572793 hasConceptScore W57572793C2779652256 @default.
- W57572793 hasConceptScore W57572793C2780148635 @default.
- W57572793 hasConceptScore W57572793C2780393176 @default.
- W57572793 hasConceptScore W57572793C2780680797 @default.
- W57572793 hasConceptScore W57572793C2780906641 @default.
- W57572793 hasConceptScore W57572793C2992333117 @default.
- W57572793 hasConceptScore W57572793C54355233 @default.
- W57572793 hasConceptScore W57572793C86803240 @default.
- W57572793 hasConceptScore W57572793C95444343 @default.
- W57572793 hasLocation W575727931 @default.
- W57572793 hasOpenAccess W57572793 @default.
- W57572793 hasPrimaryLocation W575727931 @default.
- W57572793 hasRelatedWork W1732777283 @default.
- W57572793 hasRelatedWork W1850427633 @default.
- W57572793 hasRelatedWork W1968377601 @default.
- W57572793 hasRelatedWork W1973052265 @default.
- W57572793 hasRelatedWork W2006273621 @default.
- W57572793 hasRelatedWork W2019638997 @default.
- W57572793 hasRelatedWork W2028518963 @default.
- W57572793 hasRelatedWork W2031913002 @default.
- W57572793 hasRelatedWork W2042599258 @default.
- W57572793 hasRelatedWork W2044374679 @default.
- W57572793 hasRelatedWork W2050373894 @default.
- W57572793 hasRelatedWork W2051757490 @default.
- W57572793 hasRelatedWork W2058088781 @default.
- W57572793 hasRelatedWork W2067086844 @default.
- W57572793 hasRelatedWork W2089393377 @default.
- W57572793 hasRelatedWork W2091207278 @default.
- W57572793 hasRelatedWork W2164806806 @default.
- W57572793 hasRelatedWork W2402524712 @default.
- W57572793 hasRelatedWork W2409813184 @default.
- W57572793 hasRelatedWork W2896965919 @default.
- W57572793 isParatext "false" @default.
- W57572793 isRetracted "false" @default.
- W57572793 magId "57572793" @default.
- W57572793 workType "dissertation" @default.