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• W57577109 abstract "By using [1-14C]butyrate, the fluxes of butyrate to acetate and fatty acids were measured in rat hepatocytes. Both fluxes were inhibited to a similar extent by (-)-hydroxycitrate, with no significant effect on butyrate uptake. These results indicate that acetate formation takes place in the cytoplasm, presumably via ATP-stimulated acetyl-CoA hydrolase. Since acetate formation occurred despite a net uptake of acetate, the results are also consistent with the operation of a substrate cycle between acetate and acetyl-CoA, recently proposed by other workers, and suggest that this cycle is cytoplasmic." @default.
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• W57577109 date "1989-02-01" @default.
• W57577109 modified "2023-09-27" @default.
• W57577109 title "Evidence that the production of acetate in rat hepatocytes is a predominantly cytoplasmic process" @default.
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• W57577109 doi "https://doi.org/10.1042/bj2570673" @default.
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