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- W57618881 abstract "Publisher Summary This chapter describes the effect of β-carbolines on brain cholinergic system. It reports the results of in vitro studies on tetrahydronorharmane (THN) and harmane effects on cholinergic system parameters: acetylcholinesterase (AChE), choline acetyltransferase (CAT), and muscarinic receptor from caudate nucleus and hippocampus of the rat brain. THN and harmane inhibit AChE activity from all sources. The inhibition was concentration dependent over the range studied (5 × l0 −7 –5 × 10 −5 M) when employing the biological concentrations of acetylcholine as substrate (10 −5 M). Harmane appeared to be much stronger inhibitor than THN: inhibition up to 60% was noted at 5 × 10 −5 M. No effect of both substances was seen on CAT activity. Whereas THN exerted its effect only on AChE, harmane evoked a high, concomitant inhibition of [ 3 H] QNB binding equal to 40–50% at 5 × l0 −5 M." @default.
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- W57618881 date "1980-01-01" @default.
- W57618881 modified "2023-09-27" @default.
- W57618881 title "EFFECT OF β-CARBOLINES ON BRAIN CHOLINERGIC SYSTEM" @default.
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- W57618881 doi "https://doi.org/10.1016/b978-0-08-025921-5.50056-4" @default.
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