FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W576193755> ?p ?o ?g. }

• W576193755 endingPage "49" @default.
• W576193755 startingPage "37" @default.
• W576193755 abstract "The effect of Ca(2+)-induced opening of cyclosporine-sensitive pore (mitochondrial permeability transition pore, MPTP) on the oxygen consumption and mitochondrial functional state was studied in the rat liver mitochondria. It was shown that, with the use of glutamate as oxidation substrate, in the absence of depolarization MPTP opening results in the increase of steady state respiration rate because of the activation of cyclosporine-sensitive Ca2+/H(+)-exchange and Ca2+ cycling, which was supported by the simultaneous work of MPTP and Ca(2+)-uniporter. With the aid of selective blockers, cyclosporine A and ruthenium red, it was shown that MPTP and Ca(2+)-uniporter contribute equally to the Ca(2+)-cycling and mitochondrial respiration. It was shown that bioenergetic effects of MPTP opening under steady state conditions (increase in the oxygen consumption rate under substrate oxidation without ADP, decrease in respiratory control ratio as well as the effectiveness of ATP synthesis, P/O) are close to the functional alterations, which result from the increase of endogenous proton conductance of mitochondrial membrane. Uncoupling effect of MPTP opening, by itself, had no effect on phosphorylation rate, which remains relatively stable because the fall of P/O is compensated by the activation of respiratory chain and the increase in the rate of state 3 respiration. It was concluded that under physiologically normal conditions MPTP might function as the endogenous mechanism of mild uncoupling of respiratory chain." @default.
• W576193755 created "2016-06-24" @default.
• W576193755 creator A5031893257 @default.
• W576193755 creator A5040812600 @default.
• W576193755 creator A5058336752 @default.
• W576193755 creator A5076994943 @default.
• W576193755 date "2013-10-28" @default.
• W576193755 modified "2023-09-26" @default.
• W576193755 title "The effect of Са(2+)-induced opening of cyclosporine-sensitive pore on the oxygen consumption and functional state of rat liver mitochondria" @default.
• W576193755 cites W1500939659 @default.
• W576193755 cites W1548077438 @default.
• W576193755 cites W1552401403 @default.
• W576193755 cites W1602011578 @default.
• W576193755 cites W1851479110 @default.
• W576193755 cites W1964483580 @default.
• W576193755 cites W1967203467 @default.
• W576193755 cites W1980515769 @default.
• W576193755 cites W1980969730 @default.
• W576193755 cites W1990665368 @default.
• W576193755 cites W1991238715 @default.
• W576193755 cites W1992011928 @default.
• W576193755 cites W1999588893 @default.
• W576193755 cites W2010572143 @default.
• W576193755 cites W2014842255 @default.
• W576193755 cites W2022627623 @default.
• W576193755 cites W2024022041 @default.
• W576193755 cites W2032580133 @default.
• W576193755 cites W2034862605 @default.
• W576193755 cites W2037864697 @default.
• W576193755 cites W2064347675 @default.
• W576193755 cites W2068048197 @default.
• W576193755 cites W2068649819 @default.
• W576193755 cites W2077996001 @default.
• W576193755 cites W2086675887 @default.
• W576193755 cites W2091154394 @default.
• W576193755 cites W2142773795 @default.
• W576193755 cites W2148230219 @default.
• W576193755 cites W2155038505 @default.
• W576193755 cites W2331471503 @default.
• W576193755 cites W2415710155 @default.
• W576193755 cites W982953202 @default.
• W576193755 doi "https://doi.org/10.15407/ubj85.05.037" @default.
• W576193755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24479321" @default.
• W576193755 hasPublicationYear "2013" @default.
• W576193755 type Work @default.
• W576193755 sameAs 576193755 @default.
• W576193755 citedByCount "2" @default.
• W576193755 countsByYear W5761937552018 @default.
• W576193755 countsByYear W5761937552020 @default.
• W576193755 crossrefType "journal-article" @default.
• W576193755 hasAuthorship W576193755A5031893257 @default.
• W576193755 hasAuthorship W576193755A5040812600 @default.
• W576193755 hasAuthorship W576193755A5058336752 @default.
• W576193755 hasAuthorship W576193755A5076994943 @default.
• W576193755 hasBestOaLocation W5761937551 @default.
• W576193755 hasConcept C100206155 @default.
• W576193755 hasConcept C105702510 @default.
• W576193755 hasConcept C12554922 @default.
• W576193755 hasConcept C134018914 @default.
• W576193755 hasConcept C13591479 @default.
• W576193755 hasConcept C137183658 @default.
• W576193755 hasConcept C178790620 @default.
• W576193755 hasConcept C181199279 @default.
• W576193755 hasConcept C182215343 @default.
• W576193755 hasConcept C185592680 @default.
• W576193755 hasConcept C190283241 @default.
• W576193755 hasConcept C2778674702 @default.
• W576193755 hasConcept C2779564974 @default.
• W576193755 hasConcept C2779657890 @default.
• W576193755 hasConcept C28859421 @default.
• W576193755 hasConcept C2993864201 @default.
• W576193755 hasConcept C3020377403 @default.
• W576193755 hasConcept C31573885 @default.
• W576193755 hasConcept C35341161 @default.
• W576193755 hasConcept C513476851 @default.
• W576193755 hasConcept C519063684 @default.
• W576193755 hasConcept C540031477 @default.
• W576193755 hasConcept C55493867 @default.
• W576193755 hasConcept C57600042 @default.
• W576193755 hasConcept C66517615 @default.
• W576193755 hasConcept C86803240 @default.
• W576193755 hasConcept C98539663 @default.
• W576193755 hasConceptScore W576193755C100206155 @default.
• W576193755 hasConceptScore W576193755C105702510 @default.
• W576193755 hasConceptScore W576193755C12554922 @default.
• W576193755 hasConceptScore W576193755C134018914 @default.
• W576193755 hasConceptScore W576193755C13591479 @default.
• W576193755 hasConceptScore W576193755C137183658 @default.
• W576193755 hasConceptScore W576193755C178790620 @default.
• W576193755 hasConceptScore W576193755C181199279 @default.
• W576193755 hasConceptScore W576193755C182215343 @default.
• W576193755 hasConceptScore W576193755C185592680 @default.
• W576193755 hasConceptScore W576193755C190283241 @default.
• W576193755 hasConceptScore W576193755C2778674702 @default.
• W576193755 hasConceptScore W576193755C2779564974 @default.
• W576193755 hasConceptScore W576193755C2779657890 @default.
• W576193755 hasConceptScore W576193755C28859421 @default.
• W576193755 hasConceptScore W576193755C2993864201 @default.

• next