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- W57634801 abstract "Previously the authors reported that selenium adequate rat pups were resistant to lung damage due to high O{sub 2} exposure. The present study was designed to assess whether Se-deficient pups repleted during postnatal period could also be protected from lung injury. Female SD rats were bred and fed a Se deficient diet during pregnancy. On day 2 postpartum, dams were divided into two groups and either continued on a Se{sup {minus}} diet or fed a Se supplemented diet. On day 5 postpartum, litters in each group were randomly assigned to either air or high O{sub 2} environments. Matched dams were rotated daily between litters in air and O{sub 2} for 4 days. Double-blinded, histopathologic scoring of lungs from 9 day old pup showed that Se repletion significantly reduced the incidence of septal attenuation and interstitial inflammation. Additionally lung volume of Se repleted pups were significantly enhanced. RNA/DNA ratio and glutathione concentration of lung were increased in response to hyperoxia, but unrelated to Se nutriture. These results show that postnatal Se repletion protects the developing lung from oxygen-induced injury." @default.
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- W57634801 date "1991-03-15" @default.
- W57634801 modified "2023-09-23" @default.
- W57634801 title "Selenium repletion protects neonatal rat lungs from hyperoxia" @default.
- W57634801 hasPublicationYear "1991" @default.
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