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• W576386871 abstract "A T49696 OTKA projekt (3 ev) tamogatasaval elert főbb eredmenyek: Kimutattuk, hogy a sejtmembran tutajok szfingolipid es koleszterin alkotoelemei fontos szabalyozoi a T sejtek aktivacio/sejthalal egyensulyanak, valamint a polarizalt helper T sejtek valaszkepessegenek. Megmutattuk ezen folyamatokban a ceramidok, a Kv es Cav ioncsatornak alapvető szerepet is. Az altalunk leirt szignalintegracios modell ujabb immunmodulacios lehetősegeket kinal. Kimutattuk, hogy az osztrogen steroid hormonok gyors, nem-genomialis jeleket indukalnak T es B limfocitakon (foszforilacio, szelektiv kalcium szignal, stb.), egy meg nem azonositott membranreceptoron keresztul, es fokozzak a T sejt-fuggő, antigen-indukalt ellenanyagtermelest. Eredmenyeink elősegithetik az osztrogenszint es egyes autoimmunbetegsegek kozotti osszefuggesek hatterenek melyebb megerteset. Uj, koleszterin-specifikus IgG monoklonalis ellenanyagokat (AC1, AC8) allitottunk elő, melyeknek megmutattuk cellularis-koleszterin diagnosztikai celokra tortenő alkalmazhatosagat. Ezen ellenanyagok kepesek a HIV-infekcio/ termeles gatlasara monocita-makrofag es T sejteken in vitro, elsősorban a celsejtek plazmamembranjanak (lipid tutajok, HIV receptorok) molekularis atrendezese reven. A projekt eredmenyeit felhasznalva 2 PhD tudomanyos fokozat szuletett; 6 referalt tudomanyos kozlemeny nemzetkozi folyoiratban; 4 uj kongresszusi absztrakt, melyekből folyamatos a publikalas (3 publikacio-kesz kozlemeny) | Main results of the project T49696 supported by OTKA (3 years): We have shown that two lipid constituents of rafts (sphingolipids or cholesterol) are critical in regulating the balance of activation/cell death signaling in T cells or the functional responses of polarized Th1 or Th2 cells. Specific, important contribution of ceramides, Kv and Cav ion channels was also shown in these processes, offering new possibilites of immunomodulation. Rapid, non-genomial signals (selective phosphorylation and Ca2+ signals or NFκB nuclear translocation) of estrogen steroid hormones have been shown in both T and B lymphocytes, that may be partly responsible for augmentation of the T-dependent humoral immune response observed in in vivo mice studies. These effects, mediated by a yet unidentified E2 membrane receptor, may help us to reveal and understand the relationship between estrogen levels and several autoimmune diseases. We generated novel cholesterol-specific IgG antibodies (AC1 and AC8), that may serve as diagnostic markers of clustered cholesterol (cell-free or cellular). As one of their most intriguing biological activity - inhibition of HIV entry/production in vitro - has been elucidated and shown that the major mechanism of action is remodeling of the target cells' plasma membrane (rafts and HIV receptors). 2 PhD degrees were received based on these results; 6 reviewed research articles; 4 new Congress Abstracts (publication is continuous: 3 publication-ready manuscripts)" @default.
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• W576386871 date "2009-01-01" @default.
• W576386871 modified "2023-09-23" @default.
• W576386871 title "A T-sejt aktiváció/celluláris immunválasz szabályozása: membrán mikrodomén-függő immunmoduláció és az ösztrogén közvetített nem-genomiális hormonális hatások vizsgálata = Regulation of the T-cell mediated immune response: investigation of membrane microdomain-dependent immunomodulation and estrogen-mediated nongenomial hormonal effects" @default.
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