Matches in SemOpenAlex for { <https://semopenalex.org/work/W576875268> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W576875268 abstract "__Abstract__Myopia (nearsightedness) is a highly common eye condition that ispredominantly caused by an axial elongation of the eye. Myopia canusually be corrected with negative glasses, contact lenses, and/or laserrefractive surgery. Unfortunately, however, high myopia (-6 diopters ormore) can lead to structural changes in the retina and optic disc,resulting in sight-threat ening complications. Myopia results from aninterplay between genetic and environmental risk factors (eg. nearwork,. higher educational level, playing outdoors).In this thesis, we studied 130.000 patients from myopia studies from allover the world. We discovered that one third of the European populationis myopic. 1 in 3 persons with high myopia becomes blind or visuallyimpaired over time. Furthermore, we identified 26 genetic factors formyopia and 9 for axial length. These genetic factors play a role inneurotransmission, ion transport, retinoic acid metabolism, extracellularmatrix remodeling, and eye development. Additionally, we described therole of education (an environmental risk factor) in the development ofmyopia, and we provide compelling evidence of a gene-by-environmentinteraction; persons with a high genetic susceptibility and a higheducational level are more likely to develop myopia than persons withonly one of these two factors.The studies described in this thesis have provided considerable insightinto the complex genetic and environmental factors that give rise tomyopia and refractive error, and they have given us new directions fortreating and/or preventing this rising health issue." @default.
- W576875268 created "2016-06-24" @default.
- W576875268 creator A5027578520 @default.
- W576875268 date "2015-06-16" @default.
- W576875268 modified "2023-09-24" @default.
- W576875268 title "What causes myopia" @default.
- W576875268 hasPublicationYear "2015" @default.
- W576875268 type Work @default.
- W576875268 sameAs 576875268 @default.
- W576875268 citedByCount "0" @default.
- W576875268 crossrefType "journal-article" @default.
- W576875268 hasAuthorship W576875268A5027578520 @default.
- W576875268 hasConcept C118487528 @default.
- W576875268 hasConcept C119767625 @default.
- W576875268 hasConcept C259533 @default.
- W576875268 hasConcept C2776148792 @default.
- W576875268 hasConcept C2778257484 @default.
- W576875268 hasConcept C2781135284 @default.
- W576875268 hasConcept C2908647359 @default.
- W576875268 hasConcept C71924100 @default.
- W576875268 hasConcept C99454951 @default.
- W576875268 hasConceptScore W576875268C118487528 @default.
- W576875268 hasConceptScore W576875268C119767625 @default.
- W576875268 hasConceptScore W576875268C259533 @default.
- W576875268 hasConceptScore W576875268C2776148792 @default.
- W576875268 hasConceptScore W576875268C2778257484 @default.
- W576875268 hasConceptScore W576875268C2781135284 @default.
- W576875268 hasConceptScore W576875268C2908647359 @default.
- W576875268 hasConceptScore W576875268C71924100 @default.
- W576875268 hasConceptScore W576875268C99454951 @default.
- W576875268 hasLocation W5768752681 @default.
- W576875268 hasOpenAccess W576875268 @default.
- W576875268 hasPrimaryLocation W5768752681 @default.
- W576875268 hasRelatedWork W112637777 @default.
- W576875268 hasRelatedWork W1551314133 @default.
- W576875268 hasRelatedWork W1583735955 @default.
- W576875268 hasRelatedWork W2067095492 @default.
- W576875268 hasRelatedWork W2104747109 @default.
- W576875268 hasRelatedWork W2187308825 @default.
- W576875268 hasRelatedWork W2230547002 @default.
- W576875268 hasRelatedWork W2559286266 @default.
- W576875268 hasRelatedWork W2575874763 @default.
- W576875268 hasRelatedWork W2588775453 @default.
- W576875268 hasRelatedWork W2809174532 @default.
- W576875268 hasRelatedWork W2890998614 @default.
- W576875268 hasRelatedWork W2910049542 @default.
- W576875268 hasRelatedWork W2979357187 @default.
- W576875268 hasRelatedWork W2979680301 @default.
- W576875268 hasRelatedWork W3084556926 @default.
- W576875268 hasRelatedWork W3095027365 @default.
- W576875268 hasRelatedWork W3101877324 @default.
- W576875268 hasRelatedWork W3174678652 @default.
- W576875268 hasRelatedWork W2981473484 @default.
- W576875268 isParatext "false" @default.
- W576875268 isRetracted "false" @default.
- W576875268 magId "576875268" @default.
- W576875268 workType "article" @default.