Matches in SemOpenAlex for { <https://semopenalex.org/work/W577001144> ?p ?o ?g. }
- W577001144 abstract "Background. Understanding the mechanisms of simian immunodeficiency virus (SIV) emergence in a new host is a major public health priority of HIV research, as both HIV-1 and HIV-2 emerged through cross-species transmissions from their respective chimpanzee and sooty mangabey (SM) hosts. We therefore studied the factors associated with the fate of cross-species transmitted SIV infection to a new host by comparing and contrasting controlled and progressive cross-species transmitted SIV infections in an African non-human primate (NHP), the Guinea baboon (Papio papio). Baboons, a non-natural host of SIV, were previously reported to carry SIVagm from African green monkeys (AGMs) in the wild and to progress to AIDS when experimentally infected with SIVsmm from SMs.Methods. Ten baboons were intravenously infected with either SIVagmSab, the virus naturally infecting the sympatric AGMs (Chlorocebus sabaeus) or SIVsmm that naturally infects SMs (Cercocebus atys). The impact of intrinsic immunity on SIV infection was assessed by (i) monitoring temporal changes in the host restriction factor (HRF) (APOBEC3G, Trim5a, SAMHD-1, tetherin and MX2) expression in lymph nodes (LNs) by immunohistochemistry (IHC) and (ii) virus evolution through single genome amplification and sequencing.Results. Upon exposure to SIV, the viral loads (VLs) peaked at 10-14 days postinfection (dpi). Peak VLs were 2-3 logs lower in SIVsab infected baboons, who controlled the virus to undetectable levels at 28-42 dpi and then through follow-up. Conversely, SIVsmm infection was persistent throughout the follow-up and two out of four SIVsmm infected baboons showed signs of disease progression. IHC quantification revealed an increase in the expression of individual HRFs in the LNs from SIVsab infected controller baboons. Conversely, HRF expression was virtually unchanged in SIVsmm-infected baboons and in AGM natural hosts. SIV quasispecies characterization identified a mutation rate similar to that observed in the natural host in baboons infected with SIVsmm and baboons infected with SIVsab.Conclusions. Our results demonstrate that combined rather than individual action of HRFs is the major determinant of the outcome of SIV infection upon cross-species transmission. Therefore, approaches aimed at developing new animal models for HIV research should overcome the overall intrinsic immunity instead of focusing on individual factors." @default.
- W577001144 created "2016-06-24" @default.
- W577001144 creator A5082413065 @default.
- W577001144 date "2014-09-29" @default.
- W577001144 modified "2023-09-27" @default.
- W577001144 title "Factors associated with the control of SIVsab infection in baboons (papio papio)" @default.
- W577001144 cites W1564373806 @default.
- W577001144 cites W1810629547 @default.
- W577001144 cites W1842611842 @default.
- W577001144 cites W1966343819 @default.
- W577001144 cites W1974307222 @default.
- W577001144 cites W1986829091 @default.
- W577001144 cites W1990624998 @default.
- W577001144 cites W1992007798 @default.
- W577001144 cites W1993891836 @default.
- W577001144 cites W2001375348 @default.
- W577001144 cites W2002551039 @default.
- W577001144 cites W2002574877 @default.
- W577001144 cites W2003121559 @default.
- W577001144 cites W2010458160 @default.
- W577001144 cites W2023035407 @default.
- W577001144 cites W2024041349 @default.
- W577001144 cites W2027853473 @default.
- W577001144 cites W2033464993 @default.
- W577001144 cites W2035471108 @default.
- W577001144 cites W2037377877 @default.
- W577001144 cites W2041279170 @default.
- W577001144 cites W2043726848 @default.
- W577001144 cites W2047296684 @default.
- W577001144 cites W2058964902 @default.
- W577001144 cites W2069148320 @default.
- W577001144 cites W2069270564 @default.
- W577001144 cites W2069554621 @default.
- W577001144 cites W2078838277 @default.
- W577001144 cites W2082314789 @default.
- W577001144 cites W2097660625 @default.
- W577001144 cites W2099500083 @default.
- W577001144 cites W2101955894 @default.
- W577001144 cites W2102048184 @default.
- W577001144 cites W2102203216 @default.
- W577001144 cites W2107597477 @default.
- W577001144 cites W2108743658 @default.
- W577001144 cites W2111143795 @default.
- W577001144 cites W2123364760 @default.
- W577001144 cites W2123563614 @default.
- W577001144 cites W2123913956 @default.
- W577001144 cites W2127234024 @default.
- W577001144 cites W2128202160 @default.
- W577001144 cites W2134559961 @default.
- W577001144 cites W2134578475 @default.
- W577001144 cites W2136958613 @default.
- W577001144 cites W2137653311 @default.
- W577001144 cites W2139033519 @default.
- W577001144 cites W2140675472 @default.
- W577001144 cites W2143960873 @default.
- W577001144 cites W2144375618 @default.
- W577001144 cites W2144655743 @default.
- W577001144 cites W2144904664 @default.
- W577001144 cites W2148102806 @default.
- W577001144 cites W2149321099 @default.
- W577001144 cites W2154750531 @default.
- W577001144 cites W2156829363 @default.
- W577001144 cites W2159663680 @default.
- W577001144 cites W2165070219 @default.
- W577001144 cites W2167279371 @default.
- W577001144 cites W2168578033 @default.
- W577001144 cites W2321870122 @default.
- W577001144 cites W2334006145 @default.
- W577001144 hasPublicationYear "2014" @default.
- W577001144 type Work @default.
- W577001144 sameAs 577001144 @default.
- W577001144 citedByCount "0" @default.
- W577001144 crossrefType "journal-article" @default.
- W577001144 hasAuthorship W577001144A5082413065 @default.
- W577001144 hasConcept C134018914 @default.
- W577001144 hasConcept C159047783 @default.
- W577001144 hasConcept C169760540 @default.
- W577001144 hasConcept C203014093 @default.
- W577001144 hasConcept C2522874641 @default.
- W577001144 hasConcept C2777995582 @default.
- W577001144 hasConcept C2779175743 @default.
- W577001144 hasConcept C2779594886 @default.
- W577001144 hasConcept C2780509455 @default.
- W577001144 hasConcept C2781458928 @default.
- W577001144 hasConcept C2910145492 @default.
- W577001144 hasConcept C86803240 @default.
- W577001144 hasConceptScore W577001144C134018914 @default.
- W577001144 hasConceptScore W577001144C159047783 @default.
- W577001144 hasConceptScore W577001144C169760540 @default.
- W577001144 hasConceptScore W577001144C203014093 @default.
- W577001144 hasConceptScore W577001144C2522874641 @default.
- W577001144 hasConceptScore W577001144C2777995582 @default.
- W577001144 hasConceptScore W577001144C2779175743 @default.
- W577001144 hasConceptScore W577001144C2779594886 @default.
- W577001144 hasConceptScore W577001144C2780509455 @default.
- W577001144 hasConceptScore W577001144C2781458928 @default.
- W577001144 hasConceptScore W577001144C2910145492 @default.
- W577001144 hasConceptScore W577001144C86803240 @default.
- W577001144 hasLocation W5770011441 @default.
- W577001144 hasOpenAccess W577001144 @default.