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- W577087730 abstract "© 2001 by CRC Press LLC. Multicellular organisms are formed by compartments of different composition. To maintain this compartmentalization, they possess specialized cells, epithelia and endothelia, that form selective barriers. These cells are polarized in an apical and a basolateral cell surface domain and establish an intercellular junctional complex. In epithelial cells, the most apical structure of the junctional complex is the zonula occludens or tight junction (TJ) (see Chapter 1 by Anderson and Cereijido and Chapter 2 by Schneeberger and Lyunch; Farquhar and Palade, 1963). TJs act as a fence between the apical and basolateral cell surface domains and regulate the diffusion of molecules through the paracellular space. Different types of extracellular stimuli were found to modify transepithelial electrical resistance (TER) and paracellular permeability (see Chapter 15 by Turner and Madara, Chapter 16 by Lewis, and Chapter 18 by Nguyen et al.), the two experimental parameters that are commonly used to characterize the junctional paracellular barrier (see Chapter 4 by Reuss). Moreover, recent evidence shows that these two TJ functions can be dissociated (i.e., modified independently) from each other (Balda et al., 1996a; McCarthy et al., 1996; Calderon et al., 1998; Hasegawa et al., 1999), and that TJ proteins also participate in signaling processes that govern gene expression and differentiation (Balda and Matter, 2000a; Li and Mrsny, 2000; Nakamura et al., 2000; Reichert et al., 2000; Ryeom et al., 2000)." @default.
- W577087730 created "2016-06-24" @default.
- W577087730 creator A5005379813 @default.
- W577087730 creator A5062859833 @default.
- W577087730 creator A5086674978 @default.
- W577087730 date "2001-06-26" @default.
- W577087730 modified "2023-10-16" @default.
- W577087730 title "Intracellular Signaling in Classical and New Tight Junction Functions" @default.
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