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- W577200757 abstract "Radioiodine (I-131) is widely used in the treatment of metastatic differentiated thyroid cancer. In 20% of the cases, however, these tumors fail to take up radioiodine as a result of progression and dedifferentiation, and treatment options for these patients are limited. Failure of iodine uptake might be reversible using redifferentiating agents. Retinoids redifferentiate a variety of cell types and increase iodine uptake in thyroid cells in vitro. There has, therefore, been interest in evaluating whether retinoids can increase the uptake of iodine, and therefore the efficacy of radioiodine in patients with metastatic thyroid cancer. In thyroid cancer, their potential to redifferentiate cells and produce increased I-131 uptake suggests a possible role in the treatment of iodine-resistant disease. Despite some studies suggesting 26–40% response rates, RA has not been consistently shown to enhance radioiodine uptake in a clinically useful way. The exact role of these agents in thyroid cancer and their mechanism of action still needs to be investigated. On the basis of the apparent redifferentiation in thyroid cancer cell lines by RA, there is significant interest in assessing the efficacy of RA in restoring radioiodine uptake in patients with recurrent or metastatic thyroid cancer." @default.
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- W577200757 date "2009-01-01" @default.
- W577200757 modified "2023-09-23" @default.
- W577200757 title "Using Retinoids to Increase Radioiodine Uptake in Thyroid Cancer" @default.
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- W577200757 doi "https://doi.org/10.1016/b978-0-12-374135-6.00102-3" @default.
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