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- W57720179 abstract "This chapter reviews the findings relevant to the tuftsin receptor focusing on: the distribution in various body cells, specificity of the tuftsin-receptor interaction and its parameters, membrane and cellular events that proceed following peptide–cell encounter, and the receptor's nature. Tuftsin is a humoral basic tetrapeptide, of the sequence L-threonyl-L-lysyl-L-prolyl-L-arginine, which has been found to manifest various biological activities associated with the reticuloendothelial and immune system function. Tuftsin has a wide range of activities that it exerts on the phagocytic cells, the polymorphonuclear leukocyte, the monocyte, and the macrophage, from human as well as from other mammalian species. Structure–function studies with numerous synthetic analogs of tuftsin have shown that the unique structural integrity of the peptide must be maintained to achieve full biological potency. Chemical alterations of the tuftsin molecule that are introduced into the main peptide chain or at the side chains lead to a reduction in the activity and sometimes to tuftsin's inhibitors." @default.
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- W57720179 date "1986-01-01" @default.
- W57720179 modified "2023-10-14" @default.
- W57720179 title "The Tuftsin Receptors" @default.
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- W57720179 doi "https://doi.org/10.1016/b978-0-12-185203-0.50014-8" @default.
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