Matches in SemOpenAlex for { <https://semopenalex.org/work/W577355148> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W577355148 abstract "This PhD thesis is a study of cortical electrophysiology in two basal ganglia disorders: Parkinson’s disease (PD) and dystonia. Two diseases were chosen as being representative of hypokinetic and hyperkinetic movement disorders, respectively. In addition, current treatments seem to be imperfect to control many aspects of both diseases, hence the interest in exploring potential new therapeutic targets. PD and dystonia are basal ganglia diseases, but there is growing body of evidence of impaired cortical function and particularly of abnormal sensorimotor cortical plasticity in both disorders. We however still lack knowledge about functional significance of these cortical changes. Are they maladaptive or compensatory or of little functional significance? Techniques of Transcranial Magnetic (TMS) were used to determine 1) if clinical asymmetry of early PD is reflected in hemispheric asymmetry of sensorimotor cortical plasticity and intracortical inhibition, and 2) how these electrophysiological measures change with disease progression. We found that the hemisphere contralateral to the less affected side had preserved intracortical inhibition and a larger response to the plasticity protocol, whereas on the more affected hemisphere these were reduced. We further demonstrated that the decline in asymmetry of these measures correlated with the reduction in asymmetry of clinical symptoms, suggesting these were compensatory changes. In dystonia patients, we investigated using TMS 1) if change of afferent input induced by botulinum toxin injections may change response to plasticity protocol in primary dystonia, and if 2) secondary and primary dystonia patients share the same pattern of electrophysiological abnormalities. We demonstrated that sensorimotor cortical plasticity in primary dystonia is not permanent abnormality but may be transitory reduced with botulinum injections treatment. Secondary dystonia patients, as opposed to primary dystonia patients did not have enhanced sensorimotor plasticity or impaired cerebellar function. We provide evidence that different types of dystonia do not necessarily have the same neuroanatomical substrates, which might have therapeutic implications." @default.
- W577355148 created "2016-06-24" @default.
- W577355148 creator A5022579723 @default.
- W577355148 date "2014-06-28" @default.
- W577355148 modified "2023-09-24" @default.
- W577355148 title "The role of sensorimotor cortical plasticity in pathophysiology of Parkinson’s disease and dystonia" @default.
- W577355148 hasPublicationYear "2014" @default.
- W577355148 type Work @default.
- W577355148 sameAs 577355148 @default.
- W577355148 citedByCount "0" @default.
- W577355148 crossrefType "dissertation" @default.
- W577355148 hasAuthorship W577355148A5022579723 @default.
- W577355148 hasConcept C142724271 @default.
- W577355148 hasConcept C15744967 @default.
- W577355148 hasConcept C169760540 @default.
- W577355148 hasConcept C24998067 @default.
- W577355148 hasConcept C2778187257 @default.
- W577355148 hasConcept C2778261627 @default.
- W577355148 hasConcept C2778559928 @default.
- W577355148 hasConcept C2778581513 @default.
- W577355148 hasConcept C2779134260 @default.
- W577355148 hasConcept C2779494072 @default.
- W577355148 hasConcept C2779734285 @default.
- W577355148 hasConcept C47611674 @default.
- W577355148 hasConcept C529278444 @default.
- W577355148 hasConcept C71924100 @default.
- W577355148 hasConceptScore W577355148C142724271 @default.
- W577355148 hasConceptScore W577355148C15744967 @default.
- W577355148 hasConceptScore W577355148C169760540 @default.
- W577355148 hasConceptScore W577355148C24998067 @default.
- W577355148 hasConceptScore W577355148C2778187257 @default.
- W577355148 hasConceptScore W577355148C2778261627 @default.
- W577355148 hasConceptScore W577355148C2778559928 @default.
- W577355148 hasConceptScore W577355148C2778581513 @default.
- W577355148 hasConceptScore W577355148C2779134260 @default.
- W577355148 hasConceptScore W577355148C2779494072 @default.
- W577355148 hasConceptScore W577355148C2779734285 @default.
- W577355148 hasConceptScore W577355148C47611674 @default.
- W577355148 hasConceptScore W577355148C529278444 @default.
- W577355148 hasConceptScore W577355148C71924100 @default.
- W577355148 hasLocation W5773551481 @default.
- W577355148 hasOpenAccess W577355148 @default.
- W577355148 hasPrimaryLocation W5773551481 @default.
- W577355148 hasRelatedWork W1726896534 @default.
- W577355148 hasRelatedWork W1929350226 @default.
- W577355148 hasRelatedWork W1966023607 @default.
- W577355148 hasRelatedWork W2009105760 @default.
- W577355148 hasRelatedWork W2048467431 @default.
- W577355148 hasRelatedWork W2048532846 @default.
- W577355148 hasRelatedWork W2137200018 @default.
- W577355148 hasRelatedWork W2140520104 @default.
- W577355148 hasRelatedWork W2469355841 @default.
- W577355148 hasRelatedWork W2507491792 @default.
- W577355148 hasRelatedWork W2553845886 @default.
- W577355148 hasRelatedWork W2558937820 @default.
- W577355148 hasRelatedWork W2571409276 @default.
- W577355148 hasRelatedWork W2593847339 @default.
- W577355148 hasRelatedWork W2769906474 @default.
- W577355148 hasRelatedWork W2913865795 @default.
- W577355148 hasRelatedWork W2917723676 @default.
- W577355148 hasRelatedWork W2957823613 @default.
- W577355148 hasRelatedWork W3048085495 @default.
- W577355148 hasRelatedWork W3142627103 @default.
- W577355148 isParatext "false" @default.
- W577355148 isRetracted "false" @default.
- W577355148 magId "577355148" @default.
- W577355148 workType "dissertation" @default.