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• W57739416 abstract "Rosiglitazone was found to simulate mitochondrial biogenesis in mouse brain in an apolipoprotein (Apo) E isozyme-independent manner. Rosiglitazone induced both mitochondrial DNA (mtDNA) and estrogen-stimulated related receptor alpha (ESRRA) mRNA, a key regulator of mitochondrial biogenesis. Transcriptomics and proteomics analysis suggested the mitochondria produced in the presence of human ApoE3 and E4 were not as metabolically efficient as those in the wild type or ApoE knockout mice. Thus, we propose that PPARgamma agonism induces neuronal mitochondrial biogenesis and improves glucose utilization leading to improved cellular function and provides mechanistic support for the improvement in cognition observed in treatment of Alzheimer's patients with rosiglitazone." @default.
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• W57739416 date "2007-03-01" @default.
• W57739416 modified "2023-10-04" @default.
• W57739416 title "Rosiglitazone Induces Mitochondrial Biogenesis in Mouse Brain" @default.
• W57739416 doi "https://doi.org/10.3233/jad-2007-11108" @default.
• W57739416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17361034" @default.
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