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• W577475191 abstract "The aim of the study was to investigate the role of integrins in anchorage dependent apoptosis (anoikis) and in vitro invasion of human breast cancer cell line MCF-7 and its multidrug resistant subline MCF-7Dox. Acquisition of MDR was associated with markedly decreased expression of collagen specific α2β1 and αvβ3 integrins, laminin specific α3β1 and α6β1 receptors and dramatic up-regulation of fibronectin specific α5β1 integrin. The MDR subline was substantially more resistant to anoikis than their wild type counterparts. Furthermore, MCF-7Dox cells secreted MMP-9 collagenase and invaded Matrigel. We demonstrate for the first time that stimulation of β1 integrin signaling strongly sensitizes MCF-7 cells to anoikis." @default.
• W577475191 created "2016-06-24" @default.
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• W577475191 date "2004-10-11" @default.
• W577475191 modified "2023-09-23" @default.
• W577475191 title "Expression of Integrins, Anchorage Dependent Apoptosis and Invasivenessof Multidrug Resistant Human Breast Carcinoma Cells" @default.
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• W577475191 doi "https://doi.org/10.17877/de290r-337" @default.
• W577475191 hasPublicationYear "2004" @default.
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