Matches in SemOpenAlex for { <https://semopenalex.org/work/W57750712> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W57750712 endingPage "10" @default.
- W57750712 startingPage "6" @default.
- W57750712 abstract "Malaria is a life-threatening disease and a major public health problem in Nigeria. According to the latest WHO estimates, there about 219 million cases of malaria in 2010 with an uncertainty range of 154 million to 289 million) and an estimated 660,000 deaths mostly among African children. To date, there is no vaccine and the parasites are becoming resistant to available drugs, this necessitates the need for the identification vaccine candidates. Pharmacoproteomic and computational biology represent an attractive alternative approach for the identification of common drug target and peptide-vaccine candidates in the pathogen. Vaccine designing is shifted from entire pathogen or whole antigen to peptide or epitope based-vaccines that are specific, safe and easy to produce. Subtractive genomic approach was used to identify non-human homologous outer membrane proteins in P. falciparum. Four hypothetical proteins were identified based on Vaxijen score and exo-membrane topology, used to produce both B-cell and T-cell mediated immunity. Propred and propred1 were used to predict promiscuos helper T-Lymphocytes (HTL), Cytotoxic T-Lymphocyte (CTL) epitopes and MHCPred for their binding affinity. Three T-cell epitopes derived from identified B-cells bind to maximum number of MHC class I and class II alleles and specifically bind to HLA alleles such as DRB1*0101 and DRB1*0401. The epitopes are LLNNNMLGS, FSVTTNITI and FNVQYAAQL show high potential to induce both B-cell and T-cell mediated immune responses. These predicted epitopes (small peptide) might be promising candidates for vaccine design against malaria. Experimental validation is required." @default.
- W57750712 created "2016-06-24" @default.
- W57750712 creator A5047494329 @default.
- W57750712 creator A5054078278 @default.
- W57750712 creator A5065883772 @default.
- W57750712 date "2014-01-01" @default.
- W57750712 modified "2023-09-24" @default.
- W57750712 title "Application of Reverse Vaccinology in Designing a Vaccine for Malaria" @default.
- W57750712 cites W1968361401 @default.
- W57750712 cites W1988878213 @default.
- W57750712 cites W1991206160 @default.
- W57750712 cites W2014586934 @default.
- W57750712 cites W2112129368 @default.
- W57750712 cites W2112941164 @default.
- W57750712 cites W2142636897 @default.
- W57750712 cites W2154202919 @default.
- W57750712 cites W2158714788 @default.
- W57750712 cites W2189455142 @default.
- W57750712 cites W2406169832 @default.
- W57750712 cites W2950693389 @default.
- W57750712 hasPublicationYear "2014" @default.
- W57750712 type Work @default.
- W57750712 sameAs 57750712 @default.
- W57750712 citedByCount "0" @default.
- W57750712 crossrefType "journal-article" @default.
- W57750712 hasAuthorship W57750712A5047494329 @default.
- W57750712 hasAuthorship W57750712A5054078278 @default.
- W57750712 hasAuthorship W57750712A5065883772 @default.
- W57750712 hasConcept C147483822 @default.
- W57750712 hasConcept C147969180 @default.
- W57750712 hasConcept C159047783 @default.
- W57750712 hasConcept C167672396 @default.
- W57750712 hasConcept C188280979 @default.
- W57750712 hasConcept C195616568 @default.
- W57750712 hasConcept C203014093 @default.
- W57750712 hasConcept C207936829 @default.
- W57750712 hasConcept C2776789287 @default.
- W57750712 hasConcept C2778048844 @default.
- W57750712 hasConcept C2778371730 @default.
- W57750712 hasConcept C2781034427 @default.
- W57750712 hasConcept C2781152039 @default.
- W57750712 hasConcept C70721500 @default.
- W57750712 hasConcept C86803240 @default.
- W57750712 hasConceptScore W57750712C147483822 @default.
- W57750712 hasConceptScore W57750712C147969180 @default.
- W57750712 hasConceptScore W57750712C159047783 @default.
- W57750712 hasConceptScore W57750712C167672396 @default.
- W57750712 hasConceptScore W57750712C188280979 @default.
- W57750712 hasConceptScore W57750712C195616568 @default.
- W57750712 hasConceptScore W57750712C203014093 @default.
- W57750712 hasConceptScore W57750712C207936829 @default.
- W57750712 hasConceptScore W57750712C2776789287 @default.
- W57750712 hasConceptScore W57750712C2778048844 @default.
- W57750712 hasConceptScore W57750712C2778371730 @default.
- W57750712 hasConceptScore W57750712C2781034427 @default.
- W57750712 hasConceptScore W57750712C2781152039 @default.
- W57750712 hasConceptScore W57750712C70721500 @default.
- W57750712 hasConceptScore W57750712C86803240 @default.
- W57750712 hasIssue "1" @default.
- W57750712 hasLocation W577507121 @default.
- W57750712 hasOpenAccess W57750712 @default.
- W57750712 hasPrimaryLocation W577507121 @default.
- W57750712 hasRelatedWork W153718046 @default.
- W57750712 hasRelatedWork W1927371034 @default.
- W57750712 hasRelatedWork W2060660193 @default.
- W57750712 hasRelatedWork W2142248377 @default.
- W57750712 hasRelatedWork W2174108569 @default.
- W57750712 hasRelatedWork W2208955877 @default.
- W57750712 hasRelatedWork W2223819622 @default.
- W57750712 hasRelatedWork W2336818378 @default.
- W57750712 hasRelatedWork W2396249245 @default.
- W57750712 hasRelatedWork W2441355621 @default.
- W57750712 hasRelatedWork W2517162745 @default.
- W57750712 hasRelatedWork W2611781438 @default.
- W57750712 hasRelatedWork W2754460646 @default.
- W57750712 hasRelatedWork W2801555143 @default.
- W57750712 hasRelatedWork W2897573051 @default.
- W57750712 hasRelatedWork W3105084392 @default.
- W57750712 hasRelatedWork W3122762053 @default.
- W57750712 hasRelatedWork W3124382463 @default.
- W57750712 hasRelatedWork W3184322058 @default.
- W57750712 hasRelatedWork W3211401943 @default.
- W57750712 hasVolume "4" @default.
- W57750712 isParatext "false" @default.
- W57750712 isRetracted "false" @default.
- W57750712 magId "57750712" @default.
- W57750712 workType "article" @default.