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- W57761306 abstract "The comparative analysis of cellular accumulation of 2’, 2’-difluorodeoxycytidine 5’-triphosphate (dFdCTP) or 1-β-D-arabinofuranosylcytosine 5’-triphosphate (ara-CTP) has demonstrated a wide variation depending on which cell line was studied. Some cell lines show a nearly equal accumulation of dFdCTP and ara-CTP, while others accumulate dFdCTP to severalfold higher concentrations than ara-CTP. Both drugs, dFdC and ara-C, are activated by intracellular phosphorylation, a process in which deoxycytidine kinase (dCK) is rate limiting [1]. Intracellular accumulation and retention of ara-CTP and dFdCTP relate to cytotoxic drug activity. In contrast to ara-C, dFdC acts as an inhibitor of ribonucleotide reductase (RR) and deoxycytidylate deaminase (dCMPD) [2, 3]. Additionally, cellular elimination of dFdCTP is concentration dependent, while ara-CTP elimination occurs independently of cellular ara-CTP concentrations [1]. The present study set out to specify the mechanism responsible for differential accumulation of dFdCTP and araCTP. For this purpose the cell lines CCRF-CEM, K562, HL-60, and CHO were analyzed." @default.
- W57761306 created "2016-06-24" @default.
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- W57761306 date "1992-01-01" @default.
- W57761306 modified "2023-09-23" @default.
- W57761306 title "Enhanced Accumulation of dFdC Triphosphate in Tumor Cells with Short Retention of ARA-C Triphosphate" @default.
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- W57761306 doi "https://doi.org/10.1007/978-3-642-76591-9_43" @default.
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