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- W577704277 abstract "The purpose of this study was to determine the acute changes in clinical safety markers after one week of hypo-energetic dieting with varying levels of macronutrient distribution. Forty-four sedentary, obese women (41.5±11 yrs, 165±7 cm, 99±19 kg, 46±4.4 %, 36.4±6 kg/m2) consumed either a normal calorie control diet (CON; n=14), a higher carbohydrate (% CHO: PRO: FAT= 46: 24: 30; n=14) or higher protein (% CHO: PRO: FAT= 24: 46: 30; n=16) hypo-energetic diet (1,000 kcal/d) for a 7-day period. Subjects were given prescribed diets developed by a registered dietician in order to provide the desired macronutrient and caloric intakes. Participants reported each morning in a fasted state after 0, 1, 2, 3, 4 and 7 days of dieting and provided a blood sample for determination of clinical safety markers. Data were analyzed by repeated measures ANOVA. No significant changes (p>0.05) were noted for LDH, total protein and creatinine. Significant (p<0.05) increases over time were seen in all groups for creatine kinase while significant decreases were found for GGT. Hypo-energetic dieting appears to result in significantly (p<0.05) greater levels of ALT and AST. Subjects following the HPRO diet experienced an increase of uric acid, BUN and BUN: creatinine levels which peaked after 5 days of dieting with no further increase leading to significantly greater levels of these variables in comparison to the other groups. One week of hypo-energetic dieting with higher proportions of carbohydrate or protein is responsible for acute changes in various markers of clinical safety, however, all measures were within clinically accepted normal values." @default.
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- W577704277 date "2006-03-01" @default.
- W577704277 modified "2023-10-14" @default.
- W577704277 title "Changes in clinical safety markers after one week of hypo‐energetic dieting with different macronutrients" @default.
- W577704277 doi "https://doi.org/10.1096/fasebj.20.5.lb81" @default.
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