FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W57799217> ?p ?o ?g. }

• W57799217 endingPage "619" @default.
• W57799217 startingPage "601" @default.
• W57799217 abstract "P-selectin, expressed on activated endothelial cells and platelets, is a transmembrane glycoprotein (GP) that mediates, among others, host cell–tumor cell adhesion relevant to the process of hematogenous metastasis. The most compelling evidence for a direct role of P-selectin in the metastatic process is the pronounced inhibition of metastasis in P-selectin-deficient mice compared to wild-type controls in a colon carcinoma cell model [1–3]. Along these lines, enzymatic removal of P-selectin ligands from the colon carcinoma cell surface results in a pronounced reduction of experimental metastasis [1]. Although molecules that bind P-selectin have previously been identified in tumor cell lines [4–6], their functional roles and biological significance have not been substantiated. As has been appropriately argued in the literature [7], distinctions must be made between molecules that can bind to P-selectin under static conditions in vitro, and functional ligands that do interact with P-selectin under fluid dynamic conditions in vivo. By identifying the functional P-selectin ligand(s) on colon carcinoma cells, using an integrated approach consisting of bioengineering tools and contemporary biochemistry and molecular biology techniques, we provide guidelines for engineering novel therapeutic agents that selectively block tumor cell ligand binding function and thus interfere with metastatic spread. Such a strategy may offer specific antimetastatic efficacy without impairing other important P-selectin-mediated physiological processes [8, 9]. Alternatively, these molecules could be utilized in a targeted drug-delivery approach, which would aim at selectively or preferentially eradicating colon carcinoma cells from the vasculature." @default.
• W57799217 created "2016-06-24" @default.
• W57799217 creator A5046121155 @default.
• W57799217 creator A5049898092 @default.
• W57799217 date "2011-01-01" @default.
• W57799217 modified "2023-09-26" @default.
• W57799217 title "Hematogenous Metastasis: Roles of CD44v and Alternative Sialofucosylated Selectin Ligands" @default.
• W57799217 cites W1522536354 @default.
• W57799217 cites W1572161799 @default.
• W57799217 cites W1670186976 @default.
• W57799217 cites W1864196235 @default.
• W57799217 cites W1900762885 @default.
• W57799217 cites W1914681647 @default.
• W57799217 cites W1965104689 @default.
• W57799217 cites W1965147661 @default.
• W57799217 cites W1966126000 @default.
• W57799217 cites W1967906263 @default.
• W57799217 cites W1972709497 @default.
• W57799217 cites W1973880931 @default.
• W57799217 cites W1982200045 @default.
• W57799217 cites W1983635746 @default.
• W57799217 cites W1984952437 @default.
• W57799217 cites W1986879468 @default.
• W57799217 cites W1987174800 @default.
• W57799217 cites W1987640672 @default.
• W57799217 cites W1997504682 @default.
• W57799217 cites W2000069100 @default.
• W57799217 cites W2006450996 @default.
• W57799217 cites W2006608487 @default.
• W57799217 cites W2011682203 @default.
• W57799217 cites W2013629020 @default.
• W57799217 cites W2016531738 @default.
• W57799217 cites W2021287469 @default.
• W57799217 cites W2021680023 @default.
• W57799217 cites W2023693583 @default.
• W57799217 cites W2029244562 @default.
• W57799217 cites W2030110522 @default.
• W57799217 cites W2032616796 @default.
• W57799217 cites W2035088036 @default.
• W57799217 cites W2035362880 @default.
• W57799217 cites W2037632318 @default.
• W57799217 cites W2040305571 @default.
• W57799217 cites W2047916715 @default.
• W57799217 cites W2054131747 @default.
• W57799217 cites W2057719162 @default.
• W57799217 cites W2060529002 @default.
• W57799217 cites W2060602170 @default.
• W57799217 cites W2068691191 @default.
• W57799217 cites W2071974815 @default.
• W57799217 cites W2078363059 @default.
• W57799217 cites W2079289388 @default.
• W57799217 cites W2088001386 @default.
• W57799217 cites W2089394059 @default.
• W57799217 cites W2089435825 @default.
• W57799217 cites W2090612456 @default.
• W57799217 cites W2095484461 @default.
• W57799217 cites W2095703958 @default.
• W57799217 cites W2096029533 @default.
• W57799217 cites W2096748441 @default.
• W57799217 cites W2097959454 @default.
• W57799217 cites W2106489698 @default.
• W57799217 cites W2119811828 @default.
• W57799217 cites W2122257858 @default.
• W57799217 cites W2123695942 @default.
• W57799217 cites W2127892958 @default.
• W57799217 cites W2132363122 @default.
• W57799217 cites W2134742523 @default.
• W57799217 cites W2137997688 @default.
• W57799217 cites W2140336796 @default.
• W57799217 cites W2140449516 @default.
• W57799217 cites W2141369469 @default.
• W57799217 cites W2141386649 @default.
• W57799217 cites W2144165283 @default.
• W57799217 cites W2162390651 @default.
• W57799217 cites W2163592912 @default.
• W57799217 cites W2170200613 @default.
• W57799217 cites W2170274776 @default.
• W57799217 cites W2187061108 @default.
• W57799217 cites W2338553531 @default.
• W57799217 cites W2599640096 @default.
• W57799217 doi "https://doi.org/10.1007/978-1-4419-7877-6_32" @default.
• W57799217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21618132" @default.
• W57799217 hasPublicationYear "2011" @default.
• W57799217 type Work @default.
• W57799217 sameAs 57799217 @default.
• W57799217 citedByCount "5" @default.
• W57799217 countsByYear W577992172012 @default.
• W57799217 countsByYear W577992172013 @default.
• W57799217 countsByYear W577992172014 @default.
• W57799217 countsByYear W577992172015 @default.
• W57799217 crossrefType "book-chapter" @default.
• W57799217 hasAuthorship W57799217A5046121155 @default.
• W57799217 hasAuthorship W57799217A5049898092 @default.
• W57799217 hasConcept C121608353 @default.
• W57799217 hasConcept C126322002 @default.
• W57799217 hasConcept C155619193 @default.
• W57799217 hasConcept C185592680 @default.
• W57799217 hasConcept C2776914184 @default.

• next