FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W578056198> ?p ?o ?g. }

• W578056198 abstract "Comparative studies were conducted on the effects of catecholamines and their metabolites and other pharmacological agents on arachidonic acid (AA) metabolism and prostaglandin (PG) release by rabbit iris smooth muscle and iris microsomes. Norepinephrine (Nor) and related compounds were found to stimulate significantly the conversion of l-14C-AA into PGF2and PGE2. Nor also stimulated the basal release of PGE2 from the iris in a dose dependent manner. The Nor-stlimitation of PG synthesis was blocked by indomethacin (1.5 μM). The studies on the mechanism(s) underlying the action of catecholamines on PG synthesis revealed the following: (1) The structural requirement for maximal catecholamine stimulation of PG synthesis by the iris and iris microsomes is a catechol nucleus and ethylamine polar side-chain. Thus the deaminated metabolites of Nor had little effect on PG synthesis by the iris and iris microsomes; in contrast normetanephrine stimulated significantly PG synthesis. Furthermore, catechol inhibited PG synthesis by the iris in a dose-dependent manner. (2) In order for the amine to activate PG synthesis by the iris,the amine should be permeable to the cell membrane. Permeability studies revealed that 14C-Nor is taken up rapidly by the iris. (3) α-Adrenergic agonists stimulated PG synthesis and release by the iris, and this was blocked by phentolamine" @default.
• W578056198 created "2016-06-24" @default.
• W578056198 creator A5039047429 @default.
• W578056198 creator A5050265747 @default.
• W578056198 creator A5055493844 @default.
• W578056198 creator A5022121255 @default.
• W578056198 date "1983-01-01" @default.
• W578056198 modified "2023-09-24" @default.
• W578056198 title "Effects of Catecholamines and their Metabolites and other Pharmacological Agents on Arachidonic Acid Metabolism and Prostaglandin Release by Rabbit Iris Muscle and Iris Microsomes" @default.
• W578056198 cites W1488521817 @default.
• W578056198 cites W1508862112 @default.
• W578056198 cites W1965943817 @default.
• W578056198 cites W1968313015 @default.
• W578056198 cites W1983808715 @default.
• W578056198 cites W1996610944 @default.
• W578056198 cites W2000525777 @default.
• W578056198 cites W2018755853 @default.
• W578056198 cites W2020106476 @default.
• W578056198 cites W2021572203 @default.
• W578056198 cites W2027103257 @default.
• W578056198 cites W2027821522 @default.
• W578056198 cites W2029487918 @default.
• W578056198 cites W2031644426 @default.
• W578056198 cites W2039695299 @default.
• W578056198 cites W2048995060 @default.
• W578056198 cites W2050928726 @default.
• W578056198 cites W2053784946 @default.
• W578056198 cites W2054021443 @default.
• W578056198 cites W2065266535 @default.
• W578056198 cites W2069632555 @default.
• W578056198 cites W2074385407 @default.
• W578056198 cites W2076920305 @default.
• W578056198 cites W2084712158 @default.
• W578056198 cites W2085717833 @default.
• W578056198 cites W2088538758 @default.
• W578056198 cites W2097668386 @default.
• W578056198 cites W2103814694 @default.
• W578056198 cites W2320857190 @default.
• W578056198 cites W2405622040 @default.
• W578056198 cites W4231158804 @default.
• W578056198 doi "https://doi.org/10.1007/978-1-4612-5636-6_4" @default.
• W578056198 hasPublicationYear "1983" @default.
• W578056198 type Work @default.
• W578056198 sameAs 578056198 @default.
• W578056198 citedByCount "3" @default.
• W578056198 crossrefType "book-chapter" @default.
• W578056198 hasAuthorship W578056198A5022121255 @default.
• W578056198 hasAuthorship W578056198A5039047429 @default.
• W578056198 hasAuthorship W578056198A5050265747 @default.
• W578056198 hasAuthorship W578056198A5055493844 @default.
• W578056198 hasConcept C126322002 @default.
• W578056198 hasConcept C134018914 @default.
• W578056198 hasConcept C169760540 @default.
• W578056198 hasConcept C170493617 @default.
• W578056198 hasConcept C181199279 @default.
• W578056198 hasConcept C184297639 @default.
• W578056198 hasConcept C185592680 @default.
• W578056198 hasConcept C202751555 @default.
• W578056198 hasConcept C2776740260 @default.
• W578056198 hasConcept C2778078955 @default.
• W578056198 hasConcept C2778527774 @default.
• W578056198 hasConcept C2779503344 @default.
• W578056198 hasConcept C2780253649 @default.
• W578056198 hasConcept C2780664492 @default.
• W578056198 hasConcept C38652104 @default.
• W578056198 hasConcept C41008148 @default.
• W578056198 hasConcept C55493867 @default.
• W578056198 hasConcept C71924100 @default.
• W578056198 hasConcept C86803240 @default.
• W578056198 hasConcept C87644729 @default.
• W578056198 hasConcept C98274493 @default.
• W578056198 hasConceptScore W578056198C126322002 @default.
• W578056198 hasConceptScore W578056198C134018914 @default.
• W578056198 hasConceptScore W578056198C169760540 @default.
• W578056198 hasConceptScore W578056198C170493617 @default.
• W578056198 hasConceptScore W578056198C181199279 @default.
• W578056198 hasConceptScore W578056198C184297639 @default.
• W578056198 hasConceptScore W578056198C185592680 @default.
• W578056198 hasConceptScore W578056198C202751555 @default.
• W578056198 hasConceptScore W578056198C2776740260 @default.
• W578056198 hasConceptScore W578056198C2778078955 @default.
• W578056198 hasConceptScore W578056198C2778527774 @default.
• W578056198 hasConceptScore W578056198C2779503344 @default.
• W578056198 hasConceptScore W578056198C2780253649 @default.
• W578056198 hasConceptScore W578056198C2780664492 @default.
• W578056198 hasConceptScore W578056198C38652104 @default.
• W578056198 hasConceptScore W578056198C41008148 @default.
• W578056198 hasConceptScore W578056198C55493867 @default.
• W578056198 hasConceptScore W578056198C71924100 @default.
• W578056198 hasConceptScore W578056198C86803240 @default.
• W578056198 hasConceptScore W578056198C87644729 @default.
• W578056198 hasConceptScore W578056198C98274493 @default.
• W578056198 hasLocation W5780561981 @default.
• W578056198 hasOpenAccess W578056198 @default.
• W578056198 hasPrimaryLocation W5780561981 @default.
• W578056198 hasRelatedWork W1508862112 @default.
• W578056198 hasRelatedWork W1978733905 @default.
• W578056198 hasRelatedWork W1996548306 @default.
• W578056198 hasRelatedWork W2001699648 @default.
• W578056198 hasRelatedWork W2012625110 @default.

• next