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- W578418983 abstract "Metabolic consequences of being born small for gestational age (SGA) begin to be well known. The biological mechanisms underlying this association are still unknown. To explain this association, the particular dynamic changes in adiposity that occur during catch-up growth have been evoked. Moreover the interactions with modifications of body composition later in life seem to play an important role. Our group has been working on this field since several years. We used a population-based registry, located in the city area of Haguenau. Subjects from this cohort were selected on birth criteria: 734 subjects born full-term SGA, (BW< 10th percentile) were compared to 886 subjects born Appropriate for Gestational Age (AGA: 25th <BW<75th percentile). Subjects were followed-up prospectively between 22 and 30 years of age. We have shown that subjects born SGA gained more BMI than AGA resulting in greater fat mass with more abdominal fat. More over the risk of developing MS was twofold higher in SGA even after adjustment on gain in BMI during the follow-up. The adipose tissue was analysed qualitatively, in 80 subjects from the initial cohort were highly matched on age, gender and percentage of body fat. The glucose tolerance was assed using a euglycemic insulin clamp technique. The activity, of one key enzyme of local metabolism of glucocorticoid the 11 p-hydroxysteroid deshydrogenase de type 1 (11 β-HSD-1) enzyme, was tested, in situ, using the method of microdialysis of sub-cutaneous abdominal adipose tissue. We have also performed biopsy of adipose tissue, ARNm expression of selected genes and adipocyte morphology were studied. The llβ-HSD-1 does not seem to be implicated in the development of body fat in SGA subjects. When matched on body fat, SGA subjects have smaller adipocyte than AGA. The expression of genes implicated in low grade inflammation of adipose tissue, lipogenesis and adipose tissue macrophages cell surface markers were not influenced by the birth weight, when matched on body fat mass. Only the SCD1 expression was down-regulated by gain in weight in AGA and not SGA subjects. We have demonstrated an increased gain in BMI and body fat mass and metabolic syndrome in young adults born SGA who could be related to foetal programming. But the mechanisms explaining these anomalies are still lacking." @default.
- W578418983 created "2016-06-24" @default.
- W578418983 creator A5017106812 @default.
- W578418983 date "2010-01-01" @default.
- W578418983 modified "2023-09-22" @default.
- W578418983 title "Programmation foetale de l'insulinorésistance et du syndrôme métabolique : contribution du développement de l'adiposité à l'âge adulte dans la cohorte haguenau" @default.
- W578418983 hasPublicationYear "2010" @default.
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