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- W5794328 abstract "ABSTRACT High-dose methotrexate (V-MTX-CF) and adriamycin (ADR) were utilized as adjuvant and definitive treatment in osteogenic sarcoma. Three regimens have been investigated: 1. V-MTX-CF administered at 3-weekly intervals for 18-24 months (12 patients). 2. V-MTX-CF + ADR (day 7) administered at 4-weekly intervals following the 3-weekly schedule for 18 months (22 patients). 3. Three 4-weekly V-MTX-CF consolidating courses at the beginning, middle and end of a 12 month period with V-MTX-CF interposed between courses (25 patients). Actuarial analysis reveals that over 60% of patients are free of disease for 4+ to 72+ months. This contrasts with past experience when only 20% were cured. Additional patients were rendered free of disease by multidisciplinary treatment. Pre-operative chemotherapy administered to selected patients for limb preservation caused variable degrees of tumor destruction." @default.
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- W5794328 date "1979-01-01" @default.
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- W5794328 title "Impact of Chemotherapy on Osteogenic Sarcoma" @default.
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- W5794328 doi "https://doi.org/10.1016/b978-0-08-023200-3.50022-8" @default.
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