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- W579719046 abstract "In order to determine whether or not met enkephalin is able to modulate the in vitro activity and proliferation rate of rat prolactin cells, pituitary monolayer cultures from male rats were treated with 1O-6M met -enkephalin and an immunocytochemical and morphometric study was carried out. The opio id induced significant increases in cellular and nuclear areas (p<0.05) with respect to control dishes. The proliferation rate was determined as the labelling index for peNA by double immunocytochemistry for peNA and prolactin; met-enkephalin induced a significant increase in total PCNA-expressing cells (p<0.05), the numerical density of prolactin immunoreactive cells (p<0.05)and the proliferation rate of prolactin cells (p<O.Ol). Moreover, significant differences were observed between peNA and non-PCNA prolactin immunoreactive cells, the former showing a significantly higher nuclear area (p<0.05) with no significant differ ences in the cellular or cytoplasmic areas. These results suggest a direct action of the opioid on pituitary cells and point to the possible existence of a physiological role of the opio id in modulating the proliferation of these cells." @default.
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- W579719046 date "2019-07-22" @default.
- W579719046 modified "2023-10-07" @default.
- W579719046 title "Hyperactivity and proliferation of prolactin cells induced in vitro by met-enkephalin" @default.
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