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- W580045214 abstract "Robbins reported the existence of Factor XIII and thereafter many investigators have reported the role of factor XIII in coagulation mechanism. This enzyme has, also, some actions on atherosclerotic changes in arterial intima. In order to clarify the relation between the enzyme activity and the atherosclerotic severity, we measured the activity of factor XIII and transglutaminase in human aortas.Materials and methodsA) materials: Relatively fresh 10 human aortas were selected from forensic autopsy. The intima-media preparation was made from aortic arch, thoracic and abdominal aorta.B) measurement of factor XIII: Partigen method.C) measurement of transglutaminase activity: Modification of Dvilansky et al.ResultsWe found both factor XIII and transglutaminase activity in each stages of atherosclerosis. Factor XIII seemed to be higher, but there were no significant increases. In transglutaminase activity, however, there was lower activity in stage 4.ConclusionIn early stages of atherosclerosis, we found the some degree of enzyme activity. Laki et al reported the same result in animals, but they could not ascertain whether they were dealing with the tissue or the plasma enzyme. We also imagine that the large parts of enzyme in arterial wall may come from blood plasma, but some parts of it come from tissue itself. Factor XIII may have the important role in the dynamic balance of fibrinogen-fibrin system both in blood plasma and in arterial walls." @default.
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- W580045214 date "1975-01-01" @default.
- W580045214 modified "2023-10-02" @default.
- W580045214 title "Factor XIII and Transglutaminase Activity in Human Aorta" @default.
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- W580045214 doi "https://doi.org/10.5551/jat1973.3.2_123" @default.
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