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• W5805143 abstract "Strontium and other trace metals were determined by emission spectroscopy in 18 brains from humans with degenerative diseases. The cortex and white matter of the right occipital lobe were used to compare the trace metal content of the nervous tissues with other organs of the body, and to determine a base line for the amounts of trace metals (Pb, Fe, Mn, Cu, Zn, Mo, Co, Ag, Cr, Cd, Ba, and Sr) present in these areas. Specimens were taken also from the brains of normal adults between the ages of 25 and 50 yr. Alterations in amounts of trace metals in Huntington's chorea was disclosed in a study of three cases, which also showed that an interrelation between two or more of these elements nray be a necessary prerequisite to the causation of some diseases. In this disease, affecting predominantly the corpus striatum, although alterations in the cerebral cortex are present, there was an increase in Sr with a decrease in Cu. A reversed situation regarding Cu metabolism was shown in another disease of the corpus striatum: there is an increased Cu content in hepatolenticular degeneration. This suggests possibly that the increased amount of Cu in the tissues favors an increasedmore » activity of the cellular elements in the lenticular nucleus, while a decrease in Cu leads to the development of the choreiform movements. The demonstration of small quantities of toxic metals (i.e., Pb and As) in the brains of some individuals suggested the possible ingestion of these metals. A definite increase was seen in Pb poisoning with encephalopathy. In one case of chronic Pb poisoning, tested by the spectrochemical method, the Pb content was 1.35 mg/100 g dry tissue, as compared to a normal value of 0.31 plus or minus 0.04. Of special interest was the variation of Pb concentration from one part of the brain to another, and the different concentrations in symmetrical areas of the 2 hemispheres. This raises the question whether some areas of cortex, basal ganglia, and centrum have a greater affinity for trace metals than others. There was no correlation between cortical areas of known function and the amounts of trace metals in the tissue. Rather, in the case of some metals (i.e., Cu, Fe, Pb), the amounts are related to the composition of the tissues (gray matter vs white matter). With some (i.e., Sr) the amount of deposition seemed to be the same in both types of tissue. In others, a difference was noted between the amounts deposited in the gray matter of the cortex and the amounts in the basal ganglia. The differences noted in the amounts of trace metals in comparative areas of different individuals was not dependent upon age or metabolic state, but seemed to be greater in infants than in adults. This suggests that in early life there is considerable divergence in degree of depositions, a process which becomes stabilized in later years. In some metals (i.e., Sr, Fe) the concentrations showed small variation, while in others (i.e., Zn, Cd) there was wide divergence. It is concluded that the increase of Sr in brain in Huntington's chorea is of probable significance and may serve as a marker of this disease. (BBB)« less" @default.
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• W5805143 date "1962-09-01" @default.
• W5805143 modified "2023-09-23" @default.
• W5805143 title "Trace metals and the brain. Their contribution to the study of certain neurological disorders." @default.
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