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- W5808082 abstract "ABSTRACT Two distinct types of drug toxicity are illustrated, both with liver haem as the main target. Drugs with unsaturated side chains and certain dihydropyridines both convert liver haem into N -alkylated porphyrins but the underlying mechanisms and biological properties of the resulting pigments differ in the two cases. A monooxygenated derivative of the unsaturated drugs becomes itself bound onto one of the pyrrole nitrogen atoms of the haem of cytochrome P-450 and the N -alkylated porphyrin which is produced does not inhibit the last enzyme of haem biosynthesis, protohaem ferro-lyase. In contrast, with 3,5-diethoxycarbonyl-l,4-dihydrocollidine only the 4-methyl substituent of the drug is transferred onto the pyrrole nitrogen atom and the resulting porphyrin is a powerful inhibitor of protohaem ferro-lyase. The latter pathway involves transfer of the intact 4-alkyl group onto the pyrrole nitrogen." @default.
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- W5808082 date "1982-01-01" @default.
- W5808082 modified "2023-09-26" @default.
- W5808082 title "Liver Haem as a Target for Drug Toxicity" @default.
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- W5808082 doi "https://doi.org/10.1016/b978-0-08-028025-7.50018-4" @default.
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