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- W58081047 abstract "ABSTRACT Ethanol is among the drugs whose potencies can be predicted from their lipid solubilities. Physical chemical methods reveal what it does in this hydrophobic environment; it disorders the membrane bilayer. Order parameters are reduced by ethanol and by other alcohols, in proportion to their in vivo potency. When mice are chronically treated with ethanol, their cell membranes become tolerant to the disordering effects of ethanol, and these tolerant membranes contain more cholesterol than controls. Studies with model membranes made of egg lecithin and cholesterol showed that the sterol makes membranes more ordered, and it also blocks the disordering effect of ethanol. Furthermore, ethanol facilitates the transfer of cholesterol between membranes. We speculate that changes in membrane cholesterol, mediated by ethanol itself, may contribute to ethanol tolerance." @default.
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- W58081047 date "1982-01-01" @default.
- W58081047 modified "2023-09-23" @default.
- W58081047 title "Ethanol and Membrane Cholesterol" @default.
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- W58081047 doi "https://doi.org/10.1016/b978-0-08-028025-7.50027-5" @default.
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