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• W581014842 abstract "D-optimal designs for discrete-type responses have been derived using generalized linear mixed models, simulation based methods and analytical approximations for computing the fisher information matrix (FIM) of non-linear mixed effect models with homogeneous probabilities over time. In this work, D-optimal designs using an analytical approximation of the FIM for a dichotomous, non-homogeneous, Markov-chain phase advanced sleep non-linear mixed effect model was investigated. The non-linear mixed effect model consisted of transition probabilities of dichotomous sleep data estimated as logistic functions using piecewise linear functions. Theoretical linear and nonlinear dose effects were added to the transition probabilities to modify the probability of being in either sleep stage. D-optimal designs were computed by determining an analytical approximation the FIM for each Markov component (one where the previous state was awake and another where the previous state was asleep). Each Markov component FIM was weighted either equally or by the average probability of response being awake or asleep over the night and summed to derive the total FIM (FIMtotal). The reference designs were placebo, 0.1, 1-, 6-, 10- and 20-mg dosing for a 2- to 6-way crossover study in six dosing groups. Optimized design variables were dose and number of subjects in each dose group. The designs were validated using stochastic simulation/re-estimation (SSE). Contrary to expectations, the predicted parameter uncertainty obtained via FIMtotal was larger than the uncertainty in parameter estimates computed by SSE. Nevertheless, the D-optimal designs decreased the uncertainty of parameter estimates relative to the reference designs. Additionally, the improvement for the D-optimal designs were more pronounced using SSE than predicted via FIMtotal. Through the use of an approximate analytic solution and weighting schemes, the FIMtotal for a non-homogeneous, dichotomous Markov-chain phase advanced sleep model was computed and provided more efficient trial designs and increased nonlinear mixed-effects modeling parameter precision." @default.
• W581014842 created "2016-06-24" @default.
• W581014842 creator A5051739147 @default.
• W581014842 date "2013-01-01" @default.
• W581014842 modified "2023-09-23" @default.
• W581014842 title "Benefits of Non-Linear Mixed Effect Modeling and Optimal Design : Pre-Clinical and Clinical Study Applications" @default.
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• W581014842 cites W1481817586 @default.
• W581014842 cites W1502161641 @default.
• W581014842 cites W1507448733 @default.
• W581014842 cites W1523730492 @default.
• W581014842 cites W1525055187 @default.
• W581014842 cites W1525675428 @default.
• W581014842 cites W1538828154 @default.
• W581014842 cites W1596071257 @default.
• W581014842 cites W1750253277 @default.
• W581014842 cites W192304501 @default.
• W581014842 cites W1966428196 @default.
• W581014842 cites W1968004121 @default.
• W581014842 cites W1968678821 @default.
• W581014842 cites W1968863819 @default.
• W581014842 cites W1970844564 @default.
• W581014842 cites W1971463294 @default.
• W581014842 cites W1973097930 @default.
• W581014842 cites W1975395144 @default.
• W581014842 cites W1975521766 @default.
• W581014842 cites W1978432665 @default.
• W581014842 cites W1979892077 @default.
• W581014842 cites W1988041160 @default.
• W581014842 cites W1997752174 @default.
• W581014842 cites W1997921097 @default.
• W581014842 cites W1997993541 @default.
• W581014842 cites W1998539289 @default.
• W581014842 cites W2009809271 @default.
• W581014842 cites W2013789982 @default.
• W581014842 cites W2014581807 @default.
• W581014842 cites W2018131436 @default.
• W581014842 cites W2021854043 @default.
• W581014842 cites W2025377476 @default.
• W581014842 cites W2028645925 @default.
• W581014842 cites W2029974256 @default.
• W581014842 cites W2032615301 @default.
• W581014842 cites W2036105991 @default.
• W581014842 cites W2042642523 @default.
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• W581014842 cites W2049877722 @default.
• W581014842 cites W2051168588 @default.
• W581014842 cites W2053877403 @default.
• W581014842 cites W2058550231 @default.
• W581014842 cites W2059185356 @default.
• W581014842 cites W2061725368 @default.
• W581014842 cites W2064076655 @default.
• W581014842 cites W2066935851 @default.
• W581014842 cites W2068712300 @default.
• W581014842 cites W2070013574 @default.
• W581014842 cites W2072762256 @default.
• W581014842 cites W2078380224 @default.
• W581014842 cites W2080434055 @default.
• W581014842 cites W2080603730 @default.
• W581014842 cites W2083668821 @default.
• W581014842 cites W2085681533 @default.
• W581014842 cites W2088421586 @default.
• W581014842 cites W2093651810 @default.
• W581014842 cites W2094019929 @default.
• W581014842 cites W2095523635 @default.
• W581014842 cites W2101436962 @default.
• W581014842 cites W2105454646 @default.
• W581014842 cites W2137152671 @default.
• W581014842 cites W2140481308 @default.
• W581014842 cites W2142710921 @default.
• W581014842 cites W2145527652 @default.
• W581014842 cites W2151729293 @default.
• W581014842 cites W2165405120 @default.
• W581014842 cites W2168934042 @default.
• W581014842 cites W2171238253 @default.
• W581014842 cites W2172582324 @default.
• W581014842 cites W2180807983 @default.
• W581014842 cites W2186571892 @default.
• W581014842 cites W2337379895 @default.
• W581014842 cites W2403148400 @default.
• W581014842 cites W2416055588 @default.
• W581014842 cites W2434378559 @default.
• W581014842 cites W2466575692 @default.
• W581014842 cites W2489525877 @default.
• W581014842 cites W2884525847 @default.
• W581014842 cites W3022302886 @default.
• W581014842 cites W3097925195 @default.
• W581014842 cites W3125730391 @default.
• W581014842 cites W3166543270 @default.
• W581014842 cites W647228126 @default.
• W581014842 cites W70810410 @default.
• W581014842 cites W951227076 @default.
• W581014842 hasPublicationYear "2013" @default.
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