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- W581107858 startingPage "R518" @default.
- W581107858 abstract "The ability of superoxide (O2-) and NO to influence DNA synthesis, as estimated by [3H]thymidine incorporation in logarithmically growing cells, was evaluated in three human cell types: embryonic lung fibroblasts, skin fibroblasts, and mesangial cells. Nontoxic rates of O2- generation (0.2 nM/min-0.2 microM/min) only slightly stimulated DNA synthesis in mesangial cells (10-13% increase) and did not affect fibroblast DNA synthesis. Nontoxic rates of NO generation (0.1-10 microM/min) also had only limited effects, inhibiting DNA synthesis in lung and skin fibroblasts slightly (10-20% decrease) but not affecting mesangial cells. In all three cell types, neither O2- nor NO was generated at high enough endogenous rates to support an autocrinic regulation of DNA synthesis. This and other lines of evidence indicate that a reaction between O2- and NO is unlikely to account for their opposing effects on DNA synthesis." @default.
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- W581107858 date "1993-09-01" @default.
- W581107858 modified "2023-09-27" @default.
- W581107858 title "Nitric oxide and superoxide in cultured cells: limited production and influence on DNA synthesis" @default.
- W581107858 doi "https://doi.org/10.1152/ajpregu.1993.265.3.r518" @default.
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