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- W58127934 abstract "In our study we used three groups of animals: rodents, wild mice and white footed mice; bats, little brown bat and Brazilian free-tailed bat; primate, marmoset and humans. These groups have different longevity quotient: rodents (0.8 and 1.6); bats (8.1 and 2.7?); primates (4.2 and 2.3) respectively. We hypothesize that DNA repair ability and DNA stability might correlate with species maximum longevity. In order to study different pathways of DNA repair we treated cells with gamma-radiation (targeting base excision repair, BER) or UV-C light (targeting nucleotide excision repair, NER). We monitored cell survival as well as DNA-damage level with comet-assay. Our results indicate that bat's cells are similar to primate cells following gamma radiation – they survive better and have less damage then rodent's cells. This suggests that bats and primates have superior BER compared with rodents. However, following UV-C treatment, bat's cells are similar to rodent's cells – they are very sensitive to UV-type of damage; at same time both primate species show comparable resistance to UV, superior to rodent or bat. These results are indicating that NER pathway is not efficient in repairing DNA in rodents and bats. Study with caspase activation and ROS production are supporting our conclusion - exceptional bat's longevity is not dependant from NER pathway." @default.
- W58127934 created "2016-06-24" @default.
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- W58127934 date "2008-03-01" @default.
- W58127934 modified "2023-09-24" @default.
- W58127934 title "Comparative analysis of DNA repair pathways in mammals." @default.
- W58127934 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1239.32" @default.
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