FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W581612022> ?p ?o ?g. }

• W581612022 endingPage "4361" @default.
• W581612022 startingPage "4357" @default.
• W581612022 abstract "Thunbergia Laurifolia Linn. (TL) is one of the most familiar plants in Thai traditional medicine that is used to treat various conditions, including cancer. However, the antitumor activity of TL or its constituents has never been reported at the molecular level to support the folklore claim. The present study was designed to investigate the antitumor effect of an aqueous extract of TL in human breast cancer cells and the possible mechanism(s) of action. An aqueous crude extract was prepared from dried leaves of TL. Folin-Ciocalteu colorimetric assays were used to determine the total phenolic content. Antiproliferative and cell cycle effects were evaluated in human breast adenocarcinoma MCF-7 cells by MTT reduction assay, cell growth inhibition, clonogenic cell survival, and flow cytometric analysis. Free radical generation by the extracts was detected using electron paramagnetic resonance spectroscopy. The exposure of human breast adenocarcinoma MCF-7 cells to a TL aqueous extract resulted in decreases in cell growth, clonogenic cell survival, and cell viability in a concentration-dependent manner with an IC50 value of 843 μg/ml. Treatments with extract for 24 h at 250 μg/ml or higher induced cell cycle arrest as indicated by a significant increase of cell population in the G1 phase and a significant decrease in the S phase of the cell cycle. The capability of the aqueous extract to generate radical intermediates was observed at both high pH and near-neutral pH conditions. The findings suggest the antitumor bioactivities of TL against selected breast cancer cells may be due to induction of a G1 cell cycle arrest. Cytotoxicity and cell cycle perturbation that are associated with a high concentration of the extract could be in part explained by the total phenolic contents in the extract and the capacity to generate radical intermediates to modulate cellular proliferative signals." @default.
• W581612022 created "2016-06-24" @default.
• W581612022 creator A5001979257 @default.
• W581612022 creator A5010560801 @default.
• W581612022 creator A5018275525 @default.
• W581612022 creator A5090256427 @default.
• W581612022 date "2015-06-03" @default.
• W581612022 modified "2023-10-02" @default.
• W581612022 title "Radical Intermediate Generation and Cell Cycle Arrest by an Aqueous Extract of Thunbergia Laurifolia Linn. in Human Breast Cancer Cells" @default.
• W581612022 cites W1971665589 @default.
• W581612022 cites W1991575228 @default.
• W581612022 cites W2046277450 @default.
• W581612022 cites W2048013290 @default.
• W581612022 cites W2061108410 @default.
• W581612022 cites W2069758416 @default.
• W581612022 cites W2071033519 @default.
• W581612022 cites W2085290726 @default.
• W581612022 cites W2090140549 @default.
• W581612022 cites W2093542066 @default.
• W581612022 cites W2095180642 @default.
• W581612022 cites W2130128364 @default.
• W581612022 cites W2157558148 @default.
• W581612022 cites W2170653476 @default.
• W581612022 cites W2334103145 @default.
• W581612022 doi "https://doi.org/10.7314/apjcp.2015.16.10.4357" @default.
• W581612022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26028099" @default.
• W581612022 hasPublicationYear "2015" @default.
• W581612022 type Work @default.
• W581612022 sameAs 581612022 @default.
• W581612022 citedByCount "7" @default.
• W581612022 countsByYear W5816120222015 @default.
• W581612022 countsByYear W5816120222018 @default.
• W581612022 countsByYear W5816120222019 @default.
• W581612022 countsByYear W5816120222022 @default.
• W581612022 countsByYear W5816120222023 @default.
• W581612022 crossrefType "journal-article" @default.
• W581612022 hasAuthorship W581612022A5001979257 @default.
• W581612022 hasAuthorship W581612022A5010560801 @default.
• W581612022 hasAuthorship W581612022A5018275525 @default.
• W581612022 hasAuthorship W581612022A5090256427 @default.
• W581612022 hasBestOaLocation W5816120221 @default.
• W581612022 hasConcept C105696609 @default.
• W581612022 hasConcept C117262875 @default.
• W581612022 hasConcept C121608353 @default.
• W581612022 hasConcept C126322002 @default.
• W581612022 hasConcept C1491633281 @default.
• W581612022 hasConcept C185592680 @default.
• W581612022 hasConcept C190283241 @default.
• W581612022 hasConcept C2780783641 @default.
• W581612022 hasConcept C2908647359 @default.
• W581612022 hasConcept C29537977 @default.
• W581612022 hasConcept C55493867 @default.
• W581612022 hasConcept C62112901 @default.
• W581612022 hasConcept C71924100 @default.
• W581612022 hasConcept C96232424 @default.
• W581612022 hasConcept C99454951 @default.
• W581612022 hasConceptScore W581612022C105696609 @default.
• W581612022 hasConceptScore W581612022C117262875 @default.
• W581612022 hasConceptScore W581612022C121608353 @default.
• W581612022 hasConceptScore W581612022C126322002 @default.
• W581612022 hasConceptScore W581612022C1491633281 @default.
• W581612022 hasConceptScore W581612022C185592680 @default.
• W581612022 hasConceptScore W581612022C190283241 @default.
• W581612022 hasConceptScore W581612022C2780783641 @default.
• W581612022 hasConceptScore W581612022C2908647359 @default.
• W581612022 hasConceptScore W581612022C29537977 @default.
• W581612022 hasConceptScore W581612022C55493867 @default.
• W581612022 hasConceptScore W581612022C62112901 @default.
• W581612022 hasConceptScore W581612022C71924100 @default.
• W581612022 hasConceptScore W581612022C96232424 @default.
• W581612022 hasConceptScore W581612022C99454951 @default.
• W581612022 hasIssue "10" @default.
• W581612022 hasLocation W5816120221 @default.
• W581612022 hasLocation W5816120222 @default.
• W581612022 hasOpenAccess W581612022 @default.
• W581612022 hasPrimaryLocation W5816120221 @default.
• W581612022 hasRelatedWork W2348417465 @default.
• W581612022 hasRelatedWork W2350294409 @default.
• W581612022 hasRelatedWork W2358789216 @default.
• W581612022 hasRelatedWork W2372283855 @default.
• W581612022 hasRelatedWork W2378222954 @default.
• W581612022 hasRelatedWork W2379033026 @default.
• W581612022 hasRelatedWork W2379615313 @default.
• W581612022 hasRelatedWork W2382230817 @default.
• W581612022 hasRelatedWork W2389851268 @default.
• W581612022 hasRelatedWork W2425474476 @default.
• W581612022 hasVolume "16" @default.
• W581612022 isParatext "false" @default.
• W581612022 isRetracted "false" @default.
• W581612022 magId "581612022" @default.
• W581612022 workType "article" @default.