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- W58230908 abstract "textabstractThe endocrine and exocrine functions of the male gonads, the testes, are regulated bygonadotrophic hormones which are secreted by the pituitary gland. Two separate gonadotrophichormones have been recognized: luteinizing hormone (LH) which influences Leydigcell function, and follicle-stimulating hormone (FSH) which affects the function of theseminiferous tubules. The secretion of gonadotrophins is stimulated by a hypothalamicfactor, luteinizing hormone-releasing hormone (LH-RH) and can be inhibited by steroidhormones which are secreted by the testes.The existence of another hormone which is produced by the seminiferous tubules in thetestis and also influences the pituitary gland in males has been suspected for many years(Mottram & Cramer, 1923). This principle appeared to be a non steroidal factor and hasbeen called by McCullagh (1932). The reality and significance of the inhibinconcept has been much debated and has received increasing attention during the past tenyears (see chapter 2). A schematic diagram on the interactions between stimulating andinhibiting substances in the regulation of the hypothalamic-pituitary-testicular axis is shownin figure 1.1.The aim of the investigations, described in this thesis was to examine the regulation ofinhibin production in and inhibin secretion from testicular tissue and to investigate thephysiological significance of this protein hormone in male reproduction." @default.
- W58230908 created "2016-06-24" @default.
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- W58230908 date "1988-02-05" @default.
- W58230908 modified "2023-09-27" @default.
- W58230908 title "Inhibin : its role in the regulation of the pituitary-testis axis." @default.
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- W58230908 hasPublicationYear "1988" @default.
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