Matches in SemOpenAlex for { <https://semopenalex.org/work/W58447757> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W58447757 endingPage "668" @default.
- W58447757 startingPage "665" @default.
- W58447757 abstract "Alveolar surfactant (exposed to air and therefore a prime target of air oxidants) is supplied with antioxidants during its intracellular formation on type-II pneumocytes [Rüstow, Haupt, Stevens and Kunze (1993) Am. J. Physiol. 265, L133-L139]. Plasmalogens can protect animal cells against lipid peroxidation caused by u.v. radiation. It has been suggested that plasmalogens play a direct role in protecting animal cell membranes against oxidative stress [Zoeller, Morand and Raetz (1988) J. Biol. Chem. 263, 11590-11596]. We investigated biosynthesis and secretion of plasmalogens and phospholipids by type-II cells of adult rat lungs. The plasmalogens of type-II cells consist of 93% ethanolamine plasmalogens (EthPlas) and 7% choline plasmalogens (ChoPlas). Plasmalogens isolated from alveolar surfactant, however, consist of 36.5% ChoPlas and 63.5% EthPlas. The different incorporation rates of [14C]hexadecanol into both types of plasmalogen by type-II pneumocytes are reflected in the relative proportions of their total cellular plasmalogen content. Type-II cells cultured in the presence of labelled hexadecanol or labelled hexadecylglycerol and of labelled palmitate secrete labelled ChoPlas and labelled phospholipids, both spontaneously and in response to isoprenaline. The spontaneous and stimulated secretion rates of labelled ChoPlas are 3-6 times higher than those of labelled EthPlas. This higher relative secretion rate of ChoPlas corresponds to its higher proportion in the total plasmalogen content of alveolar surfactant compared with type-II cells. Added extracellular surfactant-specific protein A inhibits the secretion of plasmalogens as well as that of phospholipids by type-II cells. The molecular species of EthPlas and ChoPlas isolated from type-II cells or lung lavage do not differ significantly and consist mainly of molecular species containing poly-unsaturated fatty acids. We conclude that ChoPlas are secreted partly as integral constituents of the alveolar surfactant. Type-II cells select between both types of plasmalogens for secretion as a constituent of surfactant. The intramolecular sorting signal presumably is the choline moiety." @default.
- W58447757 created "2016-06-24" @default.
- W58447757 creator A5000871771 @default.
- W58447757 creator A5014800446 @default.
- W58447757 creator A5015392763 @default.
- W58447757 creator A5018896886 @default.
- W58447757 creator A5030193495 @default.
- W58447757 creator A5085466726 @default.
- W58447757 date "1994-09-15" @default.
- W58447757 modified "2023-10-01" @default.
- W58447757 title "Synthesis and secretion of plasmalogens by type-II pneumocytes" @default.
- W58447757 cites W1321103 @default.
- W58447757 cites W1500405769 @default.
- W58447757 cites W1574033922 @default.
- W58447757 cites W1949178966 @default.
- W58447757 cites W1989159174 @default.
- W58447757 cites W2022768811 @default.
- W58447757 cites W2035395595 @default.
- W58447757 cites W2066935332 @default.
- W58447757 cites W2075682010 @default.
- W58447757 cites W2152311269 @default.
- W58447757 cites W2343336521 @default.
- W58447757 cites W2443162170 @default.
- W58447757 cites W92799999 @default.
- W58447757 doi "https://doi.org/10.1042/bj3020665" @default.
- W58447757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1137282" @default.
- W58447757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7945189" @default.
- W58447757 hasPublicationYear "1994" @default.
- W58447757 type Work @default.
- W58447757 sameAs 58447757 @default.
- W58447757 citedByCount "29" @default.
- W58447757 countsByYear W584477572014 @default.
- W58447757 countsByYear W584477572015 @default.
- W58447757 countsByYear W584477572017 @default.
- W58447757 countsByYear W584477572021 @default.
- W58447757 countsByYear W584477572023 @default.
- W58447757 crossrefType "journal-article" @default.
- W58447757 hasAuthorship W58447757A5000871771 @default.
- W58447757 hasAuthorship W58447757A5014800446 @default.
- W58447757 hasAuthorship W58447757A5015392763 @default.
- W58447757 hasAuthorship W58447757A5018896886 @default.
- W58447757 hasAuthorship W58447757A5030193495 @default.
- W58447757 hasAuthorship W58447757A5085466726 @default.
- W58447757 hasBestOaLocation W584477572 @default.
- W58447757 hasConcept C185592680 @default.
- W58447757 hasConcept C2777565452 @default.
- W58447757 hasConcept C2778918659 @default.
- W58447757 hasConcept C2781123555 @default.
- W58447757 hasConcept C28406088 @default.
- W58447757 hasConcept C3020334802 @default.
- W58447757 hasConcept C41625074 @default.
- W58447757 hasConcept C49039625 @default.
- W58447757 hasConcept C55493867 @default.
- W58447757 hasConcept C58226133 @default.
- W58447757 hasConcept C79879829 @default.
- W58447757 hasConceptScore W58447757C185592680 @default.
- W58447757 hasConceptScore W58447757C2777565452 @default.
- W58447757 hasConceptScore W58447757C2778918659 @default.
- W58447757 hasConceptScore W58447757C2781123555 @default.
- W58447757 hasConceptScore W58447757C28406088 @default.
- W58447757 hasConceptScore W58447757C3020334802 @default.
- W58447757 hasConceptScore W58447757C41625074 @default.
- W58447757 hasConceptScore W58447757C49039625 @default.
- W58447757 hasConceptScore W58447757C55493867 @default.
- W58447757 hasConceptScore W58447757C58226133 @default.
- W58447757 hasConceptScore W58447757C79879829 @default.
- W58447757 hasIssue "3" @default.
- W58447757 hasLocation W584477571 @default.
- W58447757 hasLocation W584477572 @default.
- W58447757 hasLocation W584477573 @default.
- W58447757 hasLocation W584477574 @default.
- W58447757 hasOpenAccess W58447757 @default.
- W58447757 hasPrimaryLocation W584477571 @default.
- W58447757 hasRelatedWork W1020056510 @default.
- W58447757 hasRelatedWork W2004056145 @default.
- W58447757 hasRelatedWork W2005337586 @default.
- W58447757 hasRelatedWork W2008106287 @default.
- W58447757 hasRelatedWork W2049894481 @default.
- W58447757 hasRelatedWork W2082358432 @default.
- W58447757 hasRelatedWork W2334783938 @default.
- W58447757 hasRelatedWork W2408822524 @default.
- W58447757 hasRelatedWork W2410998013 @default.
- W58447757 hasRelatedWork W2411791613 @default.
- W58447757 hasVolume "302" @default.
- W58447757 isParatext "false" @default.
- W58447757 isRetracted "false" @default.
- W58447757 magId "58447757" @default.
- W58447757 workType "article" @default.