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- W58462173 abstract "Phylloquinone (2-methyl-3-phytyl-1,4-naphthoquinone) is a conjugated isoprenoid that serves as a cardinal redox cofactor in plants and some cyanobacteria. In humans and other mammals, it is required as a vitamin (vitamin K1) for blood coagulation and bone metabolism. Until recently, the biosynthesis of phylloquinone in plants was considered identical to that of menaquinone (vitamin K2) in facultative anaerobic bacteria. It resulted that most of the plant research on phylloquinone focused historically on the study of its function, while very little was done on its metabolism per se. There is today, tough, compelling evidence that plants have evolved an unprecedented metabolic architecture to synthesize phylloquinone, including extraordinary events of gene fusion, highly divergent enzymes and a separated compartmentalization in chloroplasts and peroxisomes. Phylogenetic reconstructions also demonstrate that the plant genes involved in the formation of phylloquinone display a high degree of evolutionary chimerism owing to multiple events of horizontal gene transfer and gene losses. Plant phylloquinone biosynthesis is also connected via shared intermediates to the metabolism of salicylate, tocopherols, chlorophylls, and in some species to anthraquinones." @default.
- W58462173 created "2016-06-24" @default.
- W58462173 creator A5018760499 @default.
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- W58462173 creator A5045646349 @default.
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- W58462173 creator A5090861828 @default.
- W58462173 date "2011-01-01" @default.
- W58462173 modified "2023-09-26" @default.
- W58462173 title "Vitamin K1 (Phylloquinone)" @default.
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