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• W5846668 abstract "Cytotoxic capacity of rat macrophages (M phi) and natural killer (NK)/natural cytotoxic cells (NC) against adherent growing, solid tumor-derived target cells was evaluated, modulating the activation status of effector cells and growth conditions of target cells. Testing a panel of target cells, cytotoxicity of NK/NC and M phi was strikingly correlated so that besides of target-cell binding structures basic lysability seems to be of influence with respect to cytotoxicity rates. Varying the in vivo growth conditions of target cells altered their lysability by M phi and NK/NC cells in the sense that ascitic versus subcutaneously (sc) grown tumors were more resistant to lysis. On the other hand, in vitro culturing did not influence susceptibility for M phi, but with some tumor lines increased lysis by NK/NC cells was observed. In the rat, the activation status of M phi and NC was not age-dependent, and NK cell activity only declined slowly with age. But cytotoxic potential of M phi obviously presents a strain characteristic, different from NK/NC cell activity, only the latter two correlating in different rat strains. Experiments to augment natural cytotoxic capacity revealed that application of Corynebacterium parvum (CP) activated M phi and NK/NC cells, while sc tumor implantation only resulted in increased NK/NC cell cytotoxicity, leaving M phi unaltered." @default.
• W5846668 created "2016-06-24" @default.
• W5846668 creator A5039406779 @default.
• W5846668 creator A5048629656 @default.
• W5846668 date "1983-05-01" @default.
• W5846668 modified "2023-09-26" @default.
• W5846668 title "Solid tumor-derived target cell susceptibility to macrophages and natural killer/natural cytotoxic cells in the rat" @default.
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• W5846668 doi "https://doi.org/10.1016/s0171-2985(83)80031-x" @default.
• W5846668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6603412" @default.
• W5846668 hasPublicationYear "1983" @default.
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