Matches in SemOpenAlex for { <https://semopenalex.org/work/W585122078> ?p ?o ?g. }
- W585122078 endingPage "133" @default.
- W585122078 startingPage "126" @default.
- W585122078 abstract "<h3>Background:</h3> Accumulating evidence indicates that schizophrenia is associated with brain immune activation. While a number of reports suggest increased cytokine levels in patients with schizophrenia, many of these studies have been limited by their focus on peripheral cytokines or confounded by various antipsychotic treatments. Here, well-characterized patients with schizophrenia, all receiving olanzapine treatment, and healthy volunteers were analyzed with regard to cerebrospinal fluid (CSF) levels of cytokines. We correlated the CSF cytokine levels to previously analyzed metabolites of the kynurenine (KYN) pathway. <h3>Methods:</h3> We analyzed the CSF from patients and controls using electrochemiluminescence detection with regard to cytokines. Cell culture media from human cortical astrocytes were analyzed for KYN and kynurenic acid (KYNA) using high-pressure liquid chromatography or liquid chromatography/mass spectrometry. <h3>Results:</h3> We included 23 patients and 37 controls in our study. Patients with schizophrenia had increased CSF levels of interleukin (IL)-6 compared with healthy volunteers. In patients, we also observed a positive correlation between IL-6 and the tryptophan:KYNA ratio, indicating that IL-6 activates the KYN pathway. In line with this, application of IL-6 to cultured human astrocytes increased cell medium concentration of KYNA. <h3>Limitations:</h3> The CSF samples had been frozen and thawed twice before analysis of cytokines. Median age differed between patients and controls. When appropriate, all present analyses were adjusted for age. <h3>Conclusion:</h3> We have shown that IL-6, KYN and KYNA are elevated in patients with chronic schizophrenia, strengthening the idea of brain immune activation in patients with this disease. Our concurrent cell culture and clinical findings suggest that IL-6 induces the KYN pathway, leading to increased production of the <i>N</i>-methyl-d-aspartate receptor antagonist KYNA in patients with schizophrenia." @default.
- W585122078 created "2016-06-24" @default.
- W585122078 creator A5001100678 @default.
- W585122078 creator A5002354967 @default.
- W585122078 creator A5021367758 @default.
- W585122078 creator A5032620135 @default.
- W585122078 creator A5032912842 @default.
- W585122078 creator A5035939774 @default.
- W585122078 creator A5043788145 @default.
- W585122078 creator A5055128103 @default.
- W585122078 creator A5060545096 @default.
- W585122078 creator A5065013242 @default.
- W585122078 creator A5070016214 @default.
- W585122078 creator A5070089176 @default.
- W585122078 creator A5073739581 @default.
- W585122078 creator A5077822527 @default.
- W585122078 creator A5079169714 @default.
- W585122078 creator A5090031916 @default.
- W585122078 date "2015-03-01" @default.
- W585122078 modified "2023-10-12" @default.
- W585122078 title "Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia — significance for activation of the kynurenine pathway" @default.
- W585122078 cites W1522496820 @default.
- W585122078 cites W1597677460 @default.
- W585122078 cites W1978238793 @default.
- W585122078 cites W1984006673 @default.
- W585122078 cites W1984567634 @default.
- W585122078 cites W1986705088 @default.
- W585122078 cites W1988088217 @default.
- W585122078 cites W2003133798 @default.
- W585122078 cites W2010484804 @default.
- W585122078 cites W2013582450 @default.
- W585122078 cites W2014887893 @default.
- W585122078 cites W2015196668 @default.
- W585122078 cites W2017661386 @default.
- W585122078 cites W2018529141 @default.
- W585122078 cites W2028370746 @default.
- W585122078 cites W2030396834 @default.
- W585122078 cites W2036569944 @default.
- W585122078 cites W2038251674 @default.
- W585122078 cites W2042755650 @default.
- W585122078 cites W2045761141 @default.
- W585122078 cites W2048545238 @default.
- W585122078 cites W2050038709 @default.
- W585122078 cites W2050792638 @default.
- W585122078 cites W2056547365 @default.
- W585122078 cites W2058338914 @default.
- W585122078 cites W2059053486 @default.
- W585122078 cites W2060050678 @default.
- W585122078 cites W2062773180 @default.
- W585122078 cites W2067889266 @default.
- W585122078 cites W2072058525 @default.
- W585122078 cites W2072102207 @default.
- W585122078 cites W2081028418 @default.
- W585122078 cites W2081371327 @default.
- W585122078 cites W2082251152 @default.
- W585122078 cites W2085301448 @default.
- W585122078 cites W2088936071 @default.
- W585122078 cites W2095043596 @default.
- W585122078 cites W2095920783 @default.
- W585122078 cites W2102181001 @default.
- W585122078 cites W2108598556 @default.
- W585122078 cites W2115878653 @default.
- W585122078 cites W2118643787 @default.
- W585122078 cites W2122321808 @default.
- W585122078 cites W2131056323 @default.
- W585122078 cites W2137823415 @default.
- W585122078 cites W2139194458 @default.
- W585122078 cites W2148177365 @default.
- W585122078 cites W2320877828 @default.
- W585122078 cites W25245655 @default.
- W585122078 cites W5013723 @default.
- W585122078 doi "https://doi.org/10.1503/jpn.140126" @default.
- W585122078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4354818" @default.
- W585122078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25455350" @default.
- W585122078 hasPublicationYear "2015" @default.
- W585122078 type Work @default.
- W585122078 sameAs 585122078 @default.
- W585122078 citedByCount "164" @default.
- W585122078 countsByYear W5851220782014 @default.
- W585122078 countsByYear W5851220782015 @default.
- W585122078 countsByYear W5851220782016 @default.
- W585122078 countsByYear W5851220782017 @default.
- W585122078 countsByYear W5851220782018 @default.
- W585122078 countsByYear W5851220782019 @default.
- W585122078 countsByYear W5851220782020 @default.
- W585122078 countsByYear W5851220782021 @default.
- W585122078 countsByYear W5851220782022 @default.
- W585122078 countsByYear W5851220782023 @default.
- W585122078 crossrefType "journal-article" @default.
- W585122078 hasAuthorship W585122078A5001100678 @default.
- W585122078 hasAuthorship W585122078A5002354967 @default.
- W585122078 hasAuthorship W585122078A5021367758 @default.
- W585122078 hasAuthorship W585122078A5032620135 @default.
- W585122078 hasAuthorship W585122078A5032912842 @default.
- W585122078 hasAuthorship W585122078A5035939774 @default.
- W585122078 hasAuthorship W585122078A5043788145 @default.
- W585122078 hasAuthorship W585122078A5055128103 @default.
- W585122078 hasAuthorship W585122078A5060545096 @default.