Matches in SemOpenAlex for { <https://semopenalex.org/work/W5854496> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W5854496 endingPage "33" @default.
- W5854496 startingPage "229" @default.
- W5854496 abstract "Di(2-ethylhexyl) phthalate (DEHP) is the most commonly used plasticizer in polyvinyl chloride (PVC) plastics, and is therefore a major constituent of continuous ambulatory peritoneal dialysis (CAPD) bags. Because DEHP is not chemically bound, it leaches out of the plastic matrix. Recently, we found that leukocyte function in vitro is impaired by a mixture of metabolites of DEHP. In the present study, we investigated the metabolism of DEHP in patients on CAPD. The study group consisted of 10 stable patients, on CAPD for at least 6 months, using a plasticizer-containing PVC PD system [ANDY Plus (Fresenius Medical Care, Bad Homburg, Germany)]. Effluent dialysate and urine samples were collected over 24 hours, and a 10 mL blood sample was drawn. Concentrations of DEHP and its metabolites mono(2-ethylhexyl) phthalate (MEHP), phthalic acid (PA), and 2-ethylhexanol (2-EH) were determined in urine, dialysate, and serum using gas chromatography/mass spectrometry. Additionally, the degree of glucuronidation of the phthalic acid esters in urine were determined. In serum, dialysate, and urine, PA was the predominant metabolite of DEHP (0.205 +/- 0.067 mg/L, 0.284 +/- 0.180 mg/L, and 1.34 +/- 1.00 mg/L, respectively), but concentrations of MEHP were low (0.0100 +/- 0.0056 mg/L, 0.022 +/- 0.008 mg/L, 0.011 +/- 0.0064 mg/L, respectively). Urinary MEHP was glucuronidated to approximately 15%. PA was 35% eliminated as a glucuronide. Unlike healthy subjects, PD patients do not eliminate DEHP mainly in the form of MEHP or MEHP metabolites. They further break these compounds down to PA. The fact that concentrations of PA in urine exceed by far the respective serum concentrations indicates that PA is secreted by the kidney. Further research on the toxicological aspects of plasticizers in uremic patients should take these findings into account." @default.
- W5854496 created "2016-06-24" @default.
- W5854496 creator A5025150869 @default.
- W5854496 creator A5044440814 @default.
- W5854496 creator A5056051446 @default.
- W5854496 creator A5056090838 @default.
- W5854496 creator A5058496829 @default.
- W5854496 creator A5087812808 @default.
- W5854496 date "1999-01-01" @default.
- W5854496 modified "2023-09-26" @default.
- W5854496 title "Phthalic acid is the main metabolite of the plasticizer di(2-ethylhexyl) phthalate in peritoneal dialysis patients." @default.
- W5854496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10682108" @default.
- W5854496 hasPublicationYear "1999" @default.
- W5854496 type Work @default.
- W5854496 sameAs 5854496 @default.
- W5854496 citedByCount "6" @default.
- W5854496 countsByYear W58544962014 @default.
- W5854496 countsByYear W58544962016 @default.
- W5854496 countsByYear W58544962019 @default.
- W5854496 crossrefType "journal-article" @default.
- W5854496 hasAuthorship W5854496A5025150869 @default.
- W5854496 hasAuthorship W5854496A5044440814 @default.
- W5854496 hasAuthorship W5854496A5056051446 @default.
- W5854496 hasAuthorship W5854496A5056090838 @default.
- W5854496 hasAuthorship W5854496A5058496829 @default.
- W5854496 hasAuthorship W5854496A5087812808 @default.
- W5854496 hasConcept C126322002 @default.
- W5854496 hasConcept C178790620 @default.
- W5854496 hasConcept C185592680 @default.
- W5854496 hasConcept C2777414220 @default.
- W5854496 hasConcept C2777477808 @default.
- W5854496 hasConcept C2779056158 @default.
- W5854496 hasConcept C2780026642 @default.
- W5854496 hasConcept C2781005124 @default.
- W5854496 hasConcept C43617362 @default.
- W5854496 hasConcept C55493867 @default.
- W5854496 hasConcept C58968531 @default.
- W5854496 hasConcept C62231903 @default.
- W5854496 hasConcept C71924100 @default.
- W5854496 hasConceptScore W5854496C126322002 @default.
- W5854496 hasConceptScore W5854496C178790620 @default.
- W5854496 hasConceptScore W5854496C185592680 @default.
- W5854496 hasConceptScore W5854496C2777414220 @default.
- W5854496 hasConceptScore W5854496C2777477808 @default.
- W5854496 hasConceptScore W5854496C2779056158 @default.
- W5854496 hasConceptScore W5854496C2780026642 @default.
- W5854496 hasConceptScore W5854496C2781005124 @default.
- W5854496 hasConceptScore W5854496C43617362 @default.
- W5854496 hasConceptScore W5854496C55493867 @default.
- W5854496 hasConceptScore W5854496C58968531 @default.
- W5854496 hasConceptScore W5854496C62231903 @default.
- W5854496 hasConceptScore W5854496C71924100 @default.
- W5854496 hasLocation W58544961 @default.
- W5854496 hasOpenAccess W5854496 @default.
- W5854496 hasPrimaryLocation W58544961 @default.
- W5854496 hasRelatedWork W1980251642 @default.
- W5854496 hasRelatedWork W2002954010 @default.
- W5854496 hasRelatedWork W2022236476 @default.
- W5854496 hasRelatedWork W2023635770 @default.
- W5854496 hasRelatedWork W2064180864 @default.
- W5854496 hasRelatedWork W2383881196 @default.
- W5854496 hasRelatedWork W2512572683 @default.
- W5854496 hasRelatedWork W575005680 @default.
- W5854496 hasRelatedWork W5854496 @default.
- W5854496 hasRelatedWork W796148665 @default.
- W5854496 hasVolume "15" @default.
- W5854496 isParatext "false" @default.
- W5854496 isRetracted "false" @default.
- W5854496 magId "5854496" @default.
- W5854496 workType "article" @default.