Matches in SemOpenAlex for { <https://semopenalex.org/work/W585536892> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W585536892 endingPage "9121" @default.
- W585536892 startingPage "9121" @default.
- W585536892 abstract "9121 Background: The IRMA study reported the high prevalence of renal insufficiency (RI) in 4684 solid tumour patients, with a glomerular filtration rate (GFR) <90 ml/min for 50–60%. Furthermore, 80.1% were receiving nephrotoxic anticancer drugs and 79.9% drugs necessitating dosage adjustment. We present the results for IRMA patients with bone metastasis (BM). Methods: Subgroup analysis of IRMA patients with BM. Data collected: sex, age, weight, serum creatinine (SCR), bone metastasis (BM) and anticancer drugs. The prevalence of SCR>110 μmol/L was assessed. GFR was estimated with Cockcroft-Gault (CG) and abbreviated MDRD (aMDRD) formulae. Drugs necessitating dosage adjustment and those potentially nephrotoxic were identified. Chi-square test was used to compare the prevalence of RI between patients with BM and patients without, for all patients and for breast cancer (BC) ones. Results: 1,000 patients (BC 577) with BM were included: median age 60, mean 59.8, weight 66 kg, 659 women. The prevalence of SCR>110 μmol/L was 8.3%. That of GFR<90 ml/min was 57.9% with CG and 54.7% with aMDRD. 83.4% of treated patients received at least one drug needing dosage adjustment (or no data) and 69% received at least one nephrotoxic drug. The prevalence of RI was not statistically different between patients with or without BM. However, the prevalence of RI was significantly higher in BC patients with BM as compared to BC patients without BM (62.1 versus 56.7 %, p=0.04). Conclusions: RI is highly frequent in cancer patients with BM. Appropriate evaluation of renal function necessitates CG or aMDRD calculation. In those patients, and especially in breast cancer patients with BM, anticancer drugs should be cautiously selected regarding their potential renal toxicity and need for dosage adjustment. [Table: see text] No significant financial relationships to disclose." @default.
- W585536892 created "2016-06-24" @default.
- W585536892 creator A5023282286 @default.
- W585536892 creator A5026180389 @default.
- W585536892 creator A5033344528 @default.
- W585536892 creator A5040938888 @default.
- W585536892 creator A5044328939 @default.
- W585536892 creator A5055791669 @default.
- W585536892 creator A5059690857 @default.
- W585536892 creator A5062142808 @default.
- W585536892 creator A5062554003 @default.
- W585536892 creator A5071971525 @default.
- W585536892 date "2007-06-20" @default.
- W585536892 modified "2023-10-14" @default.
- W585536892 title "Renal insufficiency in bone metastasis cancer patients: Prevalence and implications on anticancer drugs management, subgroup analysis of the IRMA study" @default.
- W585536892 doi "https://doi.org/10.1200/jco.2007.25.18_suppl.9121" @default.
- W585536892 hasPublicationYear "2007" @default.
- W585536892 type Work @default.
- W585536892 sameAs 585536892 @default.
- W585536892 citedByCount "3" @default.
- W585536892 countsByYear W5855368922012 @default.
- W585536892 countsByYear W5855368922013 @default.
- W585536892 crossrefType "journal-article" @default.
- W585536892 hasAuthorship W585536892A5023282286 @default.
- W585536892 hasAuthorship W585536892A5026180389 @default.
- W585536892 hasAuthorship W585536892A5033344528 @default.
- W585536892 hasAuthorship W585536892A5040938888 @default.
- W585536892 hasAuthorship W585536892A5044328939 @default.
- W585536892 hasAuthorship W585536892A5055791669 @default.
- W585536892 hasAuthorship W585536892A5059690857 @default.
- W585536892 hasAuthorship W585536892A5062142808 @default.
- W585536892 hasAuthorship W585536892A5062554003 @default.
- W585536892 hasAuthorship W585536892A5071971525 @default.
- W585536892 hasConcept C121608353 @default.
- W585536892 hasConcept C126189478 @default.
- W585536892 hasConcept C126322002 @default.
- W585536892 hasConcept C126894567 @default.
- W585536892 hasConcept C141071460 @default.
- W585536892 hasConcept C159641895 @default.
- W585536892 hasConcept C187960798 @default.
- W585536892 hasConcept C2777783956 @default.
- W585536892 hasConcept C2779013556 @default.
- W585536892 hasConcept C2780306776 @default.
- W585536892 hasConcept C29730261 @default.
- W585536892 hasConcept C530470458 @default.
- W585536892 hasConcept C71924100 @default.
- W585536892 hasConcept C90924648 @default.
- W585536892 hasConcept C95190672 @default.
- W585536892 hasConceptScore W585536892C121608353 @default.
- W585536892 hasConceptScore W585536892C126189478 @default.
- W585536892 hasConceptScore W585536892C126322002 @default.
- W585536892 hasConceptScore W585536892C126894567 @default.
- W585536892 hasConceptScore W585536892C141071460 @default.
- W585536892 hasConceptScore W585536892C159641895 @default.
- W585536892 hasConceptScore W585536892C187960798 @default.
- W585536892 hasConceptScore W585536892C2777783956 @default.
- W585536892 hasConceptScore W585536892C2779013556 @default.
- W585536892 hasConceptScore W585536892C2780306776 @default.
- W585536892 hasConceptScore W585536892C29730261 @default.
- W585536892 hasConceptScore W585536892C530470458 @default.
- W585536892 hasConceptScore W585536892C71924100 @default.
- W585536892 hasConceptScore W585536892C90924648 @default.
- W585536892 hasConceptScore W585536892C95190672 @default.
- W585536892 hasIssue "18_suppl" @default.
- W585536892 hasLocation W5855368921 @default.
- W585536892 hasOpenAccess W585536892 @default.
- W585536892 hasPrimaryLocation W5855368921 @default.
- W585536892 hasRelatedWork W1972868401 @default.
- W585536892 hasRelatedWork W1976143010 @default.
- W585536892 hasRelatedWork W1997125233 @default.
- W585536892 hasRelatedWork W2093874596 @default.
- W585536892 hasRelatedWork W2408829444 @default.
- W585536892 hasRelatedWork W2409951727 @default.
- W585536892 hasRelatedWork W2416878559 @default.
- W585536892 hasRelatedWork W2566477261 @default.
- W585536892 hasRelatedWork W3152378732 @default.
- W585536892 hasRelatedWork W85206306 @default.
- W585536892 hasVolume "25" @default.
- W585536892 isParatext "false" @default.
- W585536892 isRetracted "false" @default.
- W585536892 magId "585536892" @default.
- W585536892 workType "article" @default.