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- W5855419 abstract "• A massive expression of the transferrin receptor ensures uptake of iron by neurons in the brain. • Oligodendrocytes do not contain transferrin receptors, which brings into question whether they are less capable of extracting iron under conditions where there is a shortage of iron as compared to that of neurons. • The impaired synthesis of myelin by oligodendrocytes is the key responsible factor for impaired motor function in iron deficiency. • In conditions with iron overload in the brain, ferritin expressed by microglia, and possibly also neurons, is responsible for scavenging excess iron which causes oxidative stress and damage to brain cells. • New objectives for understanding iron homeostasis in the brain should be directed toward iron uptake and intracellular transport in oligodendrocytes to learn more about why these cells are so affected by iron deficiency. In conditions with iron overload, relevant studies should include looking at possible scavenging processes that prevent iron toxicity, e.g., do neurons raise their levels of ferritin and ferroportin to increase storage and export of iron, respectively?" @default.
- W5855419 created "2016-06-24" @default.
- W5855419 creator A5028117056 @default.
- W5855419 date "2009-01-01" @default.
- W5855419 modified "2023-09-23" @default.
- W5855419 title "Iron-Metabolism in Neurons of the Motor System of the Central Nervous System: Lessons from Iron Deficiency and Overloading Pathologies" @default.
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- W5855419 doi "https://doi.org/10.1007/978-1-59745-462-9_10" @default.
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