FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W58592462> ?p ?o ?g. }

• W58592462 abstract "Publisher Summary The progress in understanding the mechanisms of T-cell activation and inactivation is currently being translated into strategies able to induce selective immunosuppression to treat different pathological situations, notably autoimmune diseases, allergies, and allograft rejection. The medical need for selective immunosuppression is very high, as the available immunosuppressive drugs are inadequate because of limited efficacy, modest selectivity, and considerable toxicity. Based on the recent progress is understanding antigen presentation to T-cells, key attack points for selective immunointervention have been identified: major histocompatibility complex molecules, T-cell receptor, CD4/CD8, and other accessory molecules. Therefore, to selectively interfere with the activation of pathogenic T-cells, immunosuppressive therapy can be essentially directed to three cellular targets: antigen-presenting cells, autoreactive T-cells, and regulatory T-cells. The common goal is to selectively inhibit the activation of pathogenic class II-restricted CD4 + T-cells. Induction of tolerance in mature pathogenic T-cells represents in theory the ideal form of specific immunotherapy not only in the treatment of autoimmune diseases, but also in induction of selective immunosuppression to control graft rejection and allergy. Peripheral tolerance can be easily and reproducibly induced in experimental models, but understanding the underlying mechanisms and optimizing protocols to implement them is far from ideal. Based on recent research, expectations have raised for exploiting the same strategies to inhibit the activation of human autoreactive T-cells. This chapter examines recent advances toward induction of selective immunosuppression potentially applicable to the treatment of autoimmune diseases, allograft rejection, and allergies." @default.
• W58592462 created "2016-06-24" @default.
• W58592462 creator A5058458204 @default.
• W58592462 creator A5082136074 @default.
• W58592462 creator A5091610468 @default.
• W58592462 date "1995-01-01" @default.
• W58592462 modified "2023-09-26" @default.
• W58592462 title "Advances in Selective Immunosuppression" @default.
• W58592462 cites W132781887 @default.
• W58592462 cites W1483769055 @default.
• W58592462 cites W1499556315 @default.
• W58592462 cites W1501452428 @default.
• W58592462 cites W1506204720 @default.
• W58592462 cites W1512033808 @default.
• W58592462 cites W1534792085 @default.
• W58592462 cites W1538079424 @default.
• W58592462 cites W1564722620 @default.
• W58592462 cites W1587395016 @default.
• W58592462 cites W1595789911 @default.
• W58592462 cites W1603233564 @default.
• W58592462 cites W1777738032 @default.
• W58592462 cites W1813912614 @default.
• W58592462 cites W1912150790 @default.
• W58592462 cites W1919714885 @default.
• W58592462 cites W1942668068 @default.
• W58592462 cites W1959677146 @default.
• W58592462 cites W1965045795 @default.
• W58592462 cites W1965691660 @default.
• W58592462 cites W1966598940 @default.
• W58592462 cites W1967582433 @default.
• W58592462 cites W1969576545 @default.
• W58592462 cites W1972354503 @default.
• W58592462 cites W1974856876 @default.
• W58592462 cites W1978411158 @default.
• W58592462 cites W1979514172 @default.
• W58592462 cites W1979518727 @default.
• W58592462 cites W1982034991 @default.
• W58592462 cites W1987930131 @default.
• W58592462 cites W1989726308 @default.
• W58592462 cites W1990568245 @default.
• W58592462 cites W1990824922 @default.
• W58592462 cites W1991834058 @default.
• W58592462 cites W1992499734 @default.
• W58592462 cites W1992678959 @default.
• W58592462 cites W1992985178 @default.
• W58592462 cites W1994142082 @default.
• W58592462 cites W1995313125 @default.
• W58592462 cites W1997827211 @default.
• W58592462 cites W2000133096 @default.
• W58592462 cites W2003913420 @default.
• W58592462 cites W2004680217 @default.
• W58592462 cites W2005204898 @default.
• W58592462 cites W2006673918 @default.
• W58592462 cites W2007157628 @default.
• W58592462 cites W2007362831 @default.
• W58592462 cites W2009254613 @default.
• W58592462 cites W2011658568 @default.
• W58592462 cites W2013092820 @default.
• W58592462 cites W2013134683 @default.
• W58592462 cites W2014954180 @default.
• W58592462 cites W2015966937 @default.
• W58592462 cites W2016387503 @default.
• W58592462 cites W2017185316 @default.
• W58592462 cites W2018740720 @default.
• W58592462 cites W2018852103 @default.
• W58592462 cites W2020317622 @default.
• W58592462 cites W2021951643 @default.
• W58592462 cites W2026891958 @default.
• W58592462 cites W2027306447 @default.
• W58592462 cites W2028146382 @default.
• W58592462 cites W2029836713 @default.
• W58592462 cites W2032169064 @default.
• W58592462 cites W2034249407 @default.
• W58592462 cites W2034265860 @default.
• W58592462 cites W2035244690 @default.
• W58592462 cites W2035960239 @default.
• W58592462 cites W2036368914 @default.
• W58592462 cites W2036571273 @default.
• W58592462 cites W2037374883 @default.
• W58592462 cites W2037916051 @default.
• W58592462 cites W2040595594 @default.
• W58592462 cites W2041404362 @default.
• W58592462 cites W2041699586 @default.
• W58592462 cites W2043287930 @default.
• W58592462 cites W2043493614 @default.
• W58592462 cites W2043745393 @default.
• W58592462 cites W2044219128 @default.
• W58592462 cites W2044316391 @default.
• W58592462 cites W2044512941 @default.
• W58592462 cites W2045757279 @default.
• W58592462 cites W2046749316 @default.
• W58592462 cites W2047743386 @default.
• W58592462 cites W2047777032 @default.
• W58592462 cites W2050062252 @default.
• W58592462 cites W2053274278 @default.
• W58592462 cites W2055485094 @default.
• W58592462 cites W2055773200 @default.
• W58592462 cites W2056181095 @default.
• W58592462 cites W2057043713 @default.
• W58592462 cites W2057831214 @default.

• next