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- W586119431 startingPage "962" @default.
- W586119431 abstract "目的：探讨血管紧张素-（1-7）[Ang-（1-7）]对血管紧张素Ⅱ（AngⅡ）诱导的大鼠肾小管上皮细胞（NRK52E）表型转化及细胞外基质分泌的影响。方法：体外培养NRK52E细胞,经Ang-（1-7）和AngⅡ（终浓度均为1×10-6mol/L）干预24、48、72、96 h后,应用细胞免疫化学法检测E-cadherin,α-SMA的表达;应用ELISA法检测细胞上清液中Ⅰ型胶原（ColⅠ）和纤维黏连蛋白（FN）的表达;采用实时荧光定量PCR（Real-tim e PCR）检测细胞中E-cadherin、α-SMA、ColⅠ和FN mRNA表达水平的变化。结果：AngⅡ作用96 h后,E-cadherin蛋白及mRNA表达显著减弱（P〈0.05）,α-SMA、ColⅠ、FN蛋白及mRNA表达显著增强（P〈0.05）;同时加入Ang-（1-7）后,与AngⅡ组比较,E-cadherin蛋白及mRNA的表达增强（P〈0.05）,α-SMA、ColⅠ、FN蛋白及mRNA表达减弱（P〈0.05）。结论：Ang-（1-7）能够抑制AngⅡ诱导的大鼠肾小管上皮细胞表型转化及细胞外基质的分泌。" @default.
- W586119431 created "2016-06-24" @default.
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- W586119431 date "2011-01-01" @default.
- W586119431 modified "2023-09-28" @default.
- W586119431 title "血管紧张素-（1-7）对血管紧张素II诱导的大鼠肾小管上皮细胞转分化的影响" @default.
- W586119431 hasPublicationYear "2011" @default.
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