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- W5863119 endingPage "143" @default.
- W5863119 startingPage "121" @default.
- W5863119 abstract "Functional pleiotropy and redundancy are characteristic features of cytokines, including interleukins, interferons, colony-stimulating factors and growth factors. These molecules exert their biological functions through specific receptors expressed on the surface of target cells. Originally it was thought that each cytokine exerts a specific effect on its particular target cell, but in fact, most cytokines exhibit a wide range of biological effects on various tissues and cells. One receptor may interfere with different signal transduction systems and multiple receptors can couple to the same signaling pathwayviacommon effectors. Therefore signaling pathways within a cell form a network with multiple interactions between different cytokine pathways. Interleukin-6 (IL-6) is an example of such a multifunctional cytokine [1] and exerts multiple effects on the immune, hematopoietic and nervous system in a finely regulated interaction with its two receptors: interleukin-6 receptor (IL-6R) and glycoprotein 130 (gp130), the component critical for signal transduction." @default.
- W5863119 created "2016-06-24" @default.
- W5863119 creator A5037109052 @default.
- W5863119 creator A5053867878 @default.
- W5863119 creator A5070313417 @default.
- W5863119 date "2001-01-01" @default.
- W5863119 modified "2023-09-27" @default.
- W5863119 title "Physiology and biochemistry of the interleukin-6 receptor complex: Implications for CNS disorders and Alzheimer’s disease" @default.
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