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- W58722357 abstract "Physiological removal of normal, old human RBC is initiated by the appearance of senescent cell antigen (SCA) which is related to band 3. Proteolysis appears to be involved in its generation because breakdown products of band 3 are observed in old, but not in young cells. To investigate the possible role of oxidation in generation of SCA, they tested the effect of free radical models on age-related parameters: (1) binding of autologous IgG as detected with /sup 125/I protein A, (2) increase in band 3 breakdown products as detected by immunoblotting, and (3) decrease in the anion transport activity (increase in K/sub E/, decrease in V/sub max/) as detected with a sulfate exchange assay. Incubation of cells with xanthine oxidase/xanthine as a direct source of free radicals resulted in formation of band 3-containing polymers, but not in any of the age-specific changes mentioned above. Treatment with malondialdehyde, the highly reactive product of lipid peroxidation, resulted in high molecular weight polymers that contained spectrin but not band 3. Control incubations with methanol and formaldehyde, by-products of the reaction in which malondialdehyde is generated, had similar effects. Again, no age-specific changes were observed. Direct oxidation with KIO/sub 3/ resulted in appearance ofmore » band 3-containing polymers and breakdown products, but did not lead to an increase in IgG binding, and affected anion transport only by decreasing the apparent V/sub max/. These results do not provide any evidence that systems used for simulating aging in vitro are valid models.« less" @default.
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- W58722357 date "1986-03-05" @default.
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- W58722357 title "Free radical models in erythrocyte (RBC) aging" @default.
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