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- W58723265 abstract "Abstract Twenty-one monoclonal antibodies (McAbs) with specificity for IgG subclasses have been produced in mice. These McAbs have been evaluated for activity and specificity in different assays: haemagglutination (HA) and haemagglutination-inhibition (HAI), ELISA and precipitation. Using an ELISA-inhibition assay or the HAI assay, the recognized IgG-subclass epitopes were located on the various domains of the heavy chain of the IgG molecule. The four anti-IgG1 McAbs react with the IgG1 determinant present on the CH2 domain. The eight anti-IgG3 McAbs recognize at least four different IgG3-specific determinants: one determinant present in the Fab part, two different epitopes located in the hinge and one determinant present on the Fc part. The nine anti-IgG4 McAbs recognize at least three different IgG4-specific determinants: one present on the CH2 region, one present on the CH3 region, while the location of the third epitope is not yet known. Based on these experiments, subclass-specific McAbs were selected to develop IgG subclass ELISAs with purified anti-IgG subclass antibodies as capture antibodies. The specificity of the obtained ELISAs was demonstrated with human sera which were deficient in one of the four IgG subclasses. These ELISAs have been used to screen more than 2000 normal blood donors for IgG-subclass deficiency (" @default.
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- W58723265 date "1989-01-01" @default.
- W58723265 modified "2023-09-27" @default.
- W58723265 title "Monoclonal Antibodies Against IgG Subclasses" @default.
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- W58723265 doi "https://doi.org/10.1016/b978-0-08-037378-2.50009-7" @default.
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