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- W58735552 abstract "Despite skeletal muscle’s regenerative capacity, injuries resulting in transection of the fibers and muscle tissue loss can lead to permanent functional loss. Studies with skeletal muscle transection injury-induced functional loss and recovery generally only use laceration models. Many severe skeletal muscle injuries however, result in the loss of muscle tissue. In order to determine the functional deficit following an injury with tissue loss, a model was developed in which portions of the lateral gastrocnemius (GAS) of Sprague-Dawley rats were removed. Maximal isometric tetanic tension and twitch tension were measured following the removal of either a 0.5cm × 1.0cm (SDEF) or a 1.0cm × 1.0cm (LDEF) piece of the GAS. The maximal force produced immediately after creation of the defect was 88.3 +/− 2.0% of the non-operated contralateral GAS force for SDEF and 76.9 +/− 3.2% for LDEF. Fourteen days post-defect, the maximal force produced was 88.1 +/− 5.6% for SDEF and 80.7 +/− 3.5% for LDEF of the control. Twenty-eight days post-defect, the maximal force produced was 80.9 +/− 1.0% for LDEF. These data suggest that little to no functional regeneration occurs in the defected muscle in the first four weeks." @default.
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- W58735552 date "2007-01-01" @default.
- W58735552 modified "2023-09-27" @default.
- W58735552 title "Skeletal Muscle Transection Injury with Tissue Loss" @default.
- W58735552 doi "https://doi.org/10.1096/fasebj.21.6.a1306-b" @default.
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