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- W58762584 abstract "Publisher Summary Obstructive sleep apnea (OSA) is a disorder characterized by instability of the upper airway, resulting in periodic alternation between functional obstructions to airflow during sleep and relative restoration of breathing, typically in the setting of an arousal or awakening. OSA leads to daytime neurocognitive impairment symptoms and is a risk factor for the development of cardiovascular disease including hypertension, stroke, heart failure, and arrhythmias. In addition, OSA may be independently linked with proinflammatory conditions including asthma and the metabolic syndrome. The mechanisms underlying the daytime impairment of OSA include increased homeostatic sleep pressure resulting from chronic partial sleep deprivation, as well as increased systemic inflammation induced by chronic intermittent hypoxia. The proposed mechanisms underlying the increased cardiovascular risk seen with OSA include activation of the sympathetic nervous system, physical vibratory trauma to structures of the head and neck, elaboration of oxidative stress and reactive oxygen species, and a systemic proinflammatory response. Systemic markers of inflammation associated with OSA include tumor necrosis factor a, leukotriene E4, C-reactive protein, interleukin 6, nuclear factor kB, and prostaglandin D2. Factors which influence an individual's susceptibility to the development of an inflammatory response to OSA may include genetics and the presence of obesity, which is, itself, a proinflammatory state." @default.
- W58762584 created "2016-06-24" @default.
- W58762584 creator A5003070224 @default.
- W58762584 creator A5014137355 @default.
- W58762584 date "2011-01-01" @default.
- W58762584 modified "2023-09-25" @default.
- W58762584 title "Inflammatory Mediators in Obstructive Sleep Apnea" @default.
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