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• W587681596 abstract "Computational haemodynamics play a central role in the understanding of blood behaviourin the cerebral vasculature, increasing our knowledge in the onset of vasculardiseases and their progression, improving diagnosis and ultimately providing betterpatient prognosis. Computer simulations hold the potential of accurately characterisingmotion of blood and its interaction with the vessel wall, providing the capability toassess surgical treatments with no danger to the patient. These aspects considerablycontribute to better understand of blood circulation processes as well as to augmentpre-treatment planning. Existing software environments for treatment planning consistof several stages, each requiring significant user interaction and processing time,significantly limiting their use in clinical scenarios.The aim of this PhD is to provide clinicians and researchers with a tool to aidin the understanding of human cerebral haemodynamics. This tool employs a highperformance fluid solver based on the lattice-Boltzmann method (coined HemeLB),high performance distributed computing and grid computing, and various advancedsoftware applications useful to efficiently set up and run patient-specific simulations.A graphical tool is used to segment the vasculature from patient-specific CT or MRdata and configure boundary conditions with ease, creating models of the vasculaturein real time. Blood flow visualisation is done in real time using in situ renderingtechniques implemented within the parallel fluid solver and aided by steering capabilities;these programming strategies allows the clinician to interactively display thesimulation results on a local workstation. A separate software application is usedto numerically compare simulation results carried out at different spatial resolutions,providing a strategy to approach numerical validation. This developed software andsupporting computational infrastructure was used to study various patient-specificintracranial aneurysms with the collaborating interventionalists at the National Hospitalfor Neurology and Neuroscience (London), using three-dimensional rotationalangiography data to define the patient-specific vasculature. Blood flow motion wasdepicted in detail by the visualisation capabilities, clearly showing vortex fluid ow features and stress distribution at the inner surface of the aneurysms and their surroundingvasculature. These investigations permitted the clinicians to rapidly assessthe risk associated with the growth and rupture of each aneurysm. The ultimate goalof this work is to aid clinical practice with an efficient easy-to-use toolkit for real-timedecision support." @default.
• W587681596 created "2016-06-24" @default.
• W587681596 creator A5057425464 @default.
• W587681596 date "2010-02-28" @default.
• W587681596 modified "2023-09-23" @default.
• W587681596 title "Lattice-Boltzmann simulations of cerebral blood flow" @default.
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