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- W58771618 abstract "According to the passenger leukocyte concept, a subset of Ia-rich (MHC class II-positive) leukocytes, carried over to the recipient within transplanted organs, provides the primary stimulus for allograft rejection 1. This concept has important implications for transplantation, since it implies that the bulk of a transplanted tissue is weakly or non-immunogenic. Thus, for some years, there has been growing interest in the idea that removal of passenger leukocytes from organs before transplantation may permit successful allografting with less recipient immunosuppression. If this could be achieved, the recipient should be less susceptible to the sometimes severe and even fatal side effects that are associated with current non-specific immunosuppressive therapies in the clinical setting." @default.
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- W58771618 date "1993-01-01" @default.
- W58771618 modified "2023-09-23" @default.
- W58771618 title "Dendritic Cells in Transplantation" @default.
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- W58771618 doi "https://doi.org/10.1007/978-1-4615-2930-9_82" @default.
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