Matches in SemOpenAlex for { <https://semopenalex.org/work/W587957453> ?p ?o ?g. }
- W587957453 endingPage "195" @default.
- W587957453 startingPage "187" @default.
- W587957453 abstract "Kisspeptin (KP), the endogenous ligand of GPR54, is a recently discovered neuropeptide shown to be involved in regulating reproductive system, anxiety-related behavior, locomotion, food intake, and suppression of metastasis across a range of cancers. KP is transcribed within the hippocampus, and GPR54 has been found in the amygdala and hippocampus, suggesting that KP might be involved in mediating learning and memory. However, the role of KP in cognition was largely unclear. Here, we investigated the role of KP-13, one of the endogenous active isoforms, in memory processes, and determined whether KP-13 could mitigate memory impairment induced by Aβ1-42 in mice, using novel object recognition (NOR) and object location recognition (OLR) tasks. Intracerebroventricular (i.c.v.) infusion of KP-13 (2μg) immediately after training not only facilitated memory formation, but also prolonged memory retention in both tasks. The memory-improving effects of KP-13 could be blocked by the GPR54 receptor antagonist, kisspeptin-234 (234), and GnRH receptors antagonist, Cetrorelix, suggesting pharmacological specificity. Then the memory-enhancing effects were also presented after infusion of KP-13 into the hippocampus. Moreover, we found that i.c.v. injection of KP-13 was able to reverse the memory impairment induced by Aβ1-42, which was inhibited by 234. To sum up, the results of our work indicate that KP-13 could facilitate memory formation and prolong memory retention through activation of the GPR54 and GnRH receptors, and suppress memory-impairing effect of Aβ1-42 through activation of the GPR54, suggesting that KP-13 may be a potential drug for enhancing memory and treating Alzheimer's disease." @default.
- W587957453 created "2016-06-24" @default.
- W587957453 creator A5009585171 @default.
- W587957453 creator A5010767512 @default.
- W587957453 creator A5017585948 @default.
- W587957453 creator A5022837441 @default.
- W587957453 creator A5028741591 @default.
- W587957453 creator A5031682845 @default.
- W587957453 creator A5043979648 @default.
- W587957453 creator A5088527171 @default.
- W587957453 date "2015-09-01" @default.
- W587957453 modified "2023-10-14" @default.
- W587957453 title "Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1–42 in mice novel object and object location recognition tasks" @default.
- W587957453 cites W1504590764 @default.
- W587957453 cites W1535456431 @default.
- W587957453 cites W1549225872 @default.
- W587957453 cites W1552123779 @default.
- W587957453 cites W1880891411 @default.
- W587957453 cites W1964711723 @default.
- W587957453 cites W1980776054 @default.
- W587957453 cites W1982117519 @default.
- W587957453 cites W1985685594 @default.
- W587957453 cites W1986384924 @default.
- W587957453 cites W1991847642 @default.
- W587957453 cites W2005265730 @default.
- W587957453 cites W2012362306 @default.
- W587957453 cites W2020116343 @default.
- W587957453 cites W2021381523 @default.
- W587957453 cites W2025769302 @default.
- W587957453 cites W2028020939 @default.
- W587957453 cites W2032263844 @default.
- W587957453 cites W2045682412 @default.
- W587957453 cites W2050188039 @default.
- W587957453 cites W2056258340 @default.
- W587957453 cites W2058478937 @default.
- W587957453 cites W2058657335 @default.
- W587957453 cites W2070478570 @default.
- W587957453 cites W2072387469 @default.
- W587957453 cites W2073665537 @default.
- W587957453 cites W2087255758 @default.
- W587957453 cites W2087738474 @default.
- W587957453 cites W2088577236 @default.
- W587957453 cites W2089584362 @default.
- W587957453 cites W2099659064 @default.
- W587957453 cites W2101379447 @default.
- W587957453 cites W2102900240 @default.
- W587957453 cites W2104958469 @default.
- W587957453 cites W2110495164 @default.
- W587957453 cites W2111338104 @default.
- W587957453 cites W2115294629 @default.
- W587957453 cites W2138868537 @default.
- W587957453 cites W2146525281 @default.
- W587957453 cites W2158477075 @default.
- W587957453 cites W2161880917 @default.
- W587957453 cites W2162059739 @default.
- W587957453 cites W2165490139 @default.
- W587957453 cites W2465875273 @default.
- W587957453 doi "https://doi.org/10.1016/j.nlm.2015.05.010" @default.
- W587957453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26103138" @default.
- W587957453 hasPublicationYear "2015" @default.
- W587957453 type Work @default.
- W587957453 sameAs 587957453 @default.
- W587957453 citedByCount "33" @default.
- W587957453 countsByYear W5879574532015 @default.
- W587957453 countsByYear W5879574532016 @default.
- W587957453 countsByYear W5879574532017 @default.
- W587957453 countsByYear W5879574532018 @default.
- W587957453 countsByYear W5879574532019 @default.
- W587957453 countsByYear W5879574532020 @default.
- W587957453 countsByYear W5879574532021 @default.
- W587957453 countsByYear W5879574532022 @default.
- W587957453 countsByYear W5879574532023 @default.
- W587957453 crossrefType "journal-article" @default.
- W587957453 hasAuthorship W587957453A5009585171 @default.
- W587957453 hasAuthorship W587957453A5010767512 @default.
- W587957453 hasAuthorship W587957453A5017585948 @default.
- W587957453 hasAuthorship W587957453A5022837441 @default.
- W587957453 hasAuthorship W587957453A5028741591 @default.
- W587957453 hasAuthorship W587957453A5031682845 @default.
- W587957453 hasAuthorship W587957453A5043979648 @default.
- W587957453 hasAuthorship W587957453A5088527171 @default.
- W587957453 hasConcept C118303440 @default.
- W587957453 hasConcept C126322002 @default.
- W587957453 hasConcept C15744967 @default.
- W587957453 hasConcept C16613235 @default.
- W587957453 hasConcept C169760540 @default.
- W587957453 hasConcept C169900460 @default.
- W587957453 hasConcept C170493617 @default.
- W587957453 hasConcept C185592680 @default.
- W587957453 hasConcept C2277912 @default.
- W587957453 hasConcept C2776808119 @default.
- W587957453 hasConcept C2776885963 @default.
- W587957453 hasConcept C2777003273 @default.
- W587957453 hasConcept C2779144063 @default.
- W587957453 hasConcept C2781161787 @default.
- W587957453 hasConcept C2909666625 @default.
- W587957453 hasConcept C3018842126 @default.
- W587957453 hasConcept C48455012 @default.